ArticleScience translational medicine2021
Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel.
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Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57citing papers in PubMed, 1 pooled it
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Direct measurement ofbioRxiv : the preprint server for biology · 2026Article
- Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemicScience advances · 2026Article
- Strevertene A, a Streptomyces-Derived Macrolide, Reveals Selective Activity against the Human ParasiteACS omega · 2026Article
- Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026Review
- Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMInternational journal for parasitology. Drugs and drug resistance · 2026Article
- Resistance evaluation and surveillance initiative for schistosomiasis treatment: study protocol for the RESIST project.BMC infectious diseases · 2026Article
- Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture.Molecular ecology resources · 2025Article
- Mechanisms underlying persistent liver fibrosis progression in Schistosoma-infected individuals post-treatment.Infectious diseases of poverty · 2025Article
- Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-ResistantPharmaceutics · 2025Review
- TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMbioRxiv : the preprint server for biology · 2025Article
- Abundant genetic variation is retained in many laboratory schistosome populations.PLoS pathogens · 2025Article
- Pooled, Long-read Sequencing for Structural Variant Characterization in Schistosome Populations.Genome biology and evolution · 2025Article
- The research contribution of the Schistosomiasis Collection at the Natural History Museum (SCAN): highlights, challenges and future directions.Infectious diseases of poverty · 2025Review
- Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni.PLoS neglected tropical diseases · 2025Article
- A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site inbioRxiv : the preprint server for biology · 2025Article
- Antischistosomal Potential of Animal-Derived Natural Products and Compounds.Microorganisms · 2025Review
- A comparative parasitological, histopathological, and proteomic analysis ofFrontiers in veterinary science · 2025Article
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Authors and funding
22 authors.
Winka Le Clec'hTexas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0002-1111-2492
Frédéric D ChevalierTexas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0003-2611-8106
Ana Carolina A MattosUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-1903-7615
Amanda StricklandTexas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0001-5839-2391
Robbie DiazTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Marina McDew-WhiteTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Claudia M RohrDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-0065-7160
Safari Kinung'hiNational Institute for Medical Research, Mwanza, United Republic of Tanzania.
Fiona AllanLondon Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.ORCID 0000-0001-6836-4124
Bonnie L WebsterLondon Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.ORCID 0000-0003-0930-9314
Joanne P WebsterLondon Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.ORCID 0000-0001-8616-4919
Aidan M EmeryLondon Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.ORCID 0000-0001-9028-8586
David RollinsonLondon Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.ORCID 0000-0003-1999-1716
Amadou Garba DjirmayRéseau International Schistosomiases Environnemental Aménagement et Lutte (RISEAL), Niamey, Niger.
Khalid M Al MashikhiDirectorate General of Health Services, Dhofar Governorate, Salalah, Sultanate of Oman.ORCID 0000-0002-9412-6821
Salem Al YafaeDirectorate General of Health Services, Dhofar Governorate, Salalah, Sultanate of Oman.
Mohamed A IdrisSultan Qaboos University, Muscat, Sultanate of Oman.ORCID 0000-0002-3246-8578
Hélène MonéHost-Pathogen-Environment Interactions Laboratory, University of Perpignan, Perpignan, France.ORCID 0000-0003-3180-344X
Gabriel MouahidHost-Pathogen-Environment Interactions Laboratory, University of Perpignan, Perpignan, France.ORCID 0000-0003-0332-5081
Philip LoVerdeUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-6592-0877
Timothy J C AndersonTexas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0002-0191-0204
Funding
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MGenetic Basis of Praziquantel ResistanceR01AI123434 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J, LOVERDE, PHILIP T · 2016 to 2020
$3.5MResolving the properties of schistosome TRPMPZQ, the target of the anthelmintic drug praziquantelR01AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Wei Liu, JONATHAN S MARCHANT · 2020 to 2026
$3.1MGenetic analysis of cercarial release in schistosomesR01AI133749 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2017 to 2021
$2.5MMOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–NCRR NIH HHS C06 RR013556NIAID NIH HHS R01 AI123434NIAID NIH HHS R01 AI133749NIAID NIH HHS R01 AI145871NIH HHS P51 OD011133Wellcome TrustWellcome Trust 104958/Z/14/ZWorld Health Organization 001
Abstract
Mass drug administration with praziquantel (PZQ) monotherapy is considered the mainstay for control and elimination of the parasites causing schistosomiasis in humans. This drug shows imperfect cure rates in the field, and parasites showing reduced PZQ response can be selected in the laboratory, but the extent of resistance in
Indexed as
AnthelminticsParasitesSchistosomiasis mansoniTransient Receptor Potential ChannelsAnimalsGenome-Wide Association StudyPraziquantelAnthelminticsPraziquantelTransient Receptor Potential Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.