ArticleCurrent protocols2021
Two-Sample Multivariable Mendelian Randomization Analysis Using R.
Article in Current protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Investigating the causal association between gut microbiota and type 2 diabetes: a meta-analysis and Mendelian randomization.Frontiers in public health · 2024Pooled it
- Article
- The effects of circulating proteins and metabolites on diabetic foot ulcer: A Mendelian randomization study and mediation analysis.Medicine · 2026Article
- The effects of micronutrients on the risk of upper gastrointestinal diseases: a two-sample Mendelian randomization study.European journal of nutrition · 2026Article
- Immunophenotype-mediated effects of plasma proteins on major depressive disorder: A two-step Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Genetic Perspective on the Relationship between Female Reproductive Traits, Exercise, and Bone Health Outcomes: Evidence from a National Database.Lifestyle genomics · 2026Article
- Identification and Validation of BATF3 as a Promising Biomarker Gene for Peripheral T-cell Lymphoma.Current medicinal chemistry · 2026Article
- Multi-omics integration and Mendelian randomization elucidate the PARP16-UPR axis driving chemoresistancein gastric cancer.Frontiers in oncology · 2026Article
- Global Burden of Polycystic Ovary Syndrome: A Systematic Analysis of Pre- and Post-Pandemic Trends from the 2021 Global Burden of Disease Study (1990-2021).International journal of women's health · 2026Article
- Interpretable machine learning and mendelian randomization identify risk factors for lower extremity arterial embolism and thrombosis.Frontiers in cardiovascular medicine · 2026Article
- Identification of senescence-related biomarkers for osteoporosis based on microarray analysis, Mendelian randomization, and experimental validation.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Effect of education on endometriosis and mediating effects: a mendelian randomization study.AJOG global reports · 2025Article
- The association between diet and bladder cancer risk: a two-sample mendelian randomization.European journal of nutrition · 2025Article
- Investigating the correlation between tea intake and glioblastoma: A Mendelian randomization study.Medicine · 2025Article
- Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study.Drugs - real world outcomes · 2025Article
- Assessing the impact of common pain medications on gut microbiota composition and metabolites: insights from a Mendelian randomization study.Journal of medical microbiology · 2025Article
- Integrating Mendelian randomization and multi-transcriptomic analyses to unveil the genetic association risk of regulatory T cell-mediated free cholesterol and gastric cancer.Discover oncology · 2025Article
- Double-Negative CD4 CD8 Absolute Count Plays a Mediating Role in the Causal Relationship Between Plasma Lipids and Parkinson's Disease: A Mendel Randomized Study.Molecular neurobiology · 2025Article
- Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women.Cancer medicine · 2025Article
- Drug Discovery and Development for Heart Failure Using Multi-Omics Approaches.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mendelian randomization is a framework that uses measured variation in genes for assessing and estimating the causal effect of an exposure on an outcome. Multivariable Mendelian randomization is an extension that can assess the causal effect of multiple exposures on an outcome, and can be advantageous when considering a set (>1) of potentially correlated candidate risk factors in evaluating the causal effect of each on a health outcome, accounting for measured pleiotropy. This can be seen, for example, in determining the causal effects of lipids and cholesterol on type 2 diabetes risk, where the correlated risk factors share genetic predictors. Similar to univariate Mendelian randomization, multivariable Mendelian randomization can be conducted using two-sample summary-level data where the gene-exposure and gene-outcome associations are derived from separate samples from the same underlying population. Here, we present a protocol for conducting a two-sample multivariable Mendelian randomization study using the 'MVMR' package in R and summary-level genetic data. We also provide a protocol for searching and obtaining instruments using available data sources in the 'MRInstruments' R package. Finally, we provide general guidelines and discuss the utility of performing a multivariable Mendelian randomization analysis for simultaneously assessing causality of multiple exposures. © 2021 Wiley Periodicals LLC. Basic Protocol: Performing a two-sample multivariable Mendelian randomization analysis using the 'MVMR' package in R and summarized genetic data Support Protocol 1: Installing the 'MVMR' R package Support Protocol 2: Obtaining instruments from the 'MRInstruments' R package.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.