ArticleJournal of applied clinical medical physics2022
Performance of a knowledge-based planning model for optimizing intensity-modulated radiotherapy plans for partial breast irradiation.
Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Knowledge-based planning for intensity-modulated proton therapy of the breast and chest wall with regional lymph nodes: development, validation, and comparative evaluation of two models.Frontiers in oncology · 2026Article
- Development and Evaluation of Knowledge-Based Treatment Plans for Chest Wall and Regional Lymph Node Irradiation.Cureus · 2026Article
- BreastWatch: A Varian Eclipse script tool for Community-Based automatic evaluation of breast treatment plans.Journal of applied clinical medical physics · 2025Article
- Knowledge-Based RapidPlan Volumetric Modulated Arc Therapy Model in Nasopharyngeal Carcinoma.Advances in radiation oncology · 2025Article
- Quality and mechanical efficiency of automated knowledge-based planning for volumetric-modulated arc therapy in head and neck cancer.Journal of applied clinical medical physics · 2025Article
- Effect of physical parameter differences on the performance of a knowledge-based partial arc VMAT RapidPlan model for left breast cancer.Frontiers in oncology · 2025Article
- Machine Learning Methods for Precision Dosing in Anticancer Drug Therapy: A Scoping Review.Clinical pharmacokinetics · 2024Article
- Dose prediction of organs at risk in patients with cervical cancer receiving brachytherapy using needle insertion based on a neural network method.BMC cancer · 2023Article
- Knowledge-based automatic plan optimization for left-sided whole breast tomotherapy.Physics and imaging in radiation oncology · 2022Article
- Performance of a knowledge-based planning model for optimizing intensity-modulated radiotherapy plans for partial breast irradiation.Journal of applied clinical medical physics · 2022Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate a knowledge-based (KB) planning model for RapidPlan, generated using a five-field intensity-modulated radiotherapy (IMRT) class solution beam strategy and rigorous dosimetric constraints for accelerated partial breast irradiation (APBI). MATERIALS AND
methodsThe RapidPlan model was configured using 64 APBI treatment plans and validated for 120 APBI patients who were not included in the training dataset. KB plan dosimetry was compared to clinical plan dosimetry, the clinical planning constraints, and the constraints used in phase III APBI trials. Dosimetric differences between clinical and KB plans were evaluated using paired two-tailed Wilcoxon signed-rank tests.
resultsKB planning was able to produce IMRT-based APBI plans in a single optimization without manual intervention that are comparable or better than the conventionally optimized, clinical plans. Comparing KB plans to clinical plans, differences in PTV, heart, contralateral breast, and ipsilateral lung dose-volume metrics were not clinically significant. The ipsilateral breast volume receiving at least 50% of the prescription dose was statistically and clinically significantly lower in the KB plans.
conclusionKB planning for IMRT-based APBI provides equivalent or better dosimetry compared to conventional inverse planning. This model may be reliably applied in clinical practice and could be used to transfer planning expertise to ensure consistency in APBI plan quality.
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