Evidence map›Paper›PMID 34936027›Full record

ReviewCellular and molecular life sciences : CMLS2021

Sexual determination in zebrafish.

Devora Aharon, Florence L Marlow

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

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  14. Regulation of early gonocyte differentiation in zebrafish.Biochemical Society transactions · 2025
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  18. Variant ribosomal DNA is essential for female differentiation in zebrafish.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  19. Lampbrush chromosomes of Danio rerio.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Devora AharonDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy, Place Box 1020, New York, NY, 10029-6574, USA.
Florence L MarlowDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy, Place Box 1020, New York, NY, 10029-6574, USA. florence.marlow@mssm.edu.ORCID http://orcid.org/0000-0002-9362-0342
Icahn School of Medicine at Mount Sinai · US

Funding

Molecular genetic basis of sex-specific differentiation of germ cellsR01GM133896 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARLOW, FLORENCE LOUISE · 2020 to 2023
$1.9M
foundation for the national institutes of health NIHR01 GM133896NIGMS NIH HHS R01 GM133896
6 · The paper itself

Abstract

Zebrafish have emerged as a major model organism to study vertebrate reproduction due to their high fecundity and external development of eggs and embryos. The mechanisms through which zebrafish determine their sex have come under extensive investigation, as they lack a definite sex-determining chromosome and appear to have a highly complex method of sex determination. Single-gene mutagenesis has been employed to isolate the function of genes that determine zebrafish sex and regulate sex-specific differentiation, and to explore the interactions of genes that promote female or male sexual fate. In this review, we focus on recent advances in understanding of the mechanisms, including genetic and environmental factors, governing zebrafish sex development with comparisons to gene functions in other species to highlight conserved and potentially species-specific mechanisms for specifying and maintaining sexual fate.

Indexed as

AnimalsFemaleGerm CellsMaleProtein Processing, Post-TranslationalRNASex Determination ProcessesSex DifferentiationZebrafishRNAGeneticsOvaryRNA binding proteinSex determinationTestis

Identifiers

PMID34936027
PMCPMC11072476
OpenAlexW4200412045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.