ArticleSchizophrenia bulletin2022
Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Motor equivalence in motor awareness.iScience · 2026Article
- Cognitive-Developmental Mechanisms in Hallucinations.Schizophrenia bulletin · 2025Review
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- Embodiment in episodic memory through premotor-hippocampal coupling.Communications biology · 2024Article
- Augmenting locomotor perception by remapping tactile foot sensation to the back.Journal of neuroengineering and rehabilitation · 2024Article
- Probing corporeal awareness in women through virtual reality induction of embreathment illusion.Scientific reports · 2024Article
- Action prediction in psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- The bodily self from psychosis to psychedelics.Scientific reports · 2023Article
- Multisensory decisions from self to world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Understanding the neural bases of bodily self-consciousness: recent achievements and main challenges.Frontiers in integrative neuroscience · 2023Review
- Sense of body ownership and body agency in schizophrenia.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one's actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.