Evidence map›Paper›PMID 34935593›Full record

ArticleThe journal of spinal cord medicine2023

The use of alkaline phosphatase as a bone turnover marker after spinal cord injury: A scoping review of human and animal studies.

Matteo Ponzano, Matheus J Wiest, André Coleman, Emily Newton, Maureen Pakosh, Eleni M Patsakos, David S K Magnuson, Lora M Giangregorio, B Catharine Craven

Open access · greenAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of spinal cord medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Matteo PonzanoKITE - Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.
Matheus J WiestKITE - Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.ORCID 0000-0003-1444-4828
André ColemanDepartment of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Emily NewtonKITE - Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.
Maureen PakoshLibrary & Information Services, University Health Network, Toronto Rehabilitation Institute, Toronto, Canada.ORCID 0000-0002-4507-3380
Eleni M PatsakosKITE - Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.ORCID 0000-0003-4256-9150
David S K MagnusonKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.
Lora M GiangregorioKITE - Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.
B Catharine CravenKITE - Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.ORCID 0000-0001-8234-6803
University Health Network · CAUniversity of Louisville · USUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum alkaline phosphatase (ALP) is measured as an indicator of bone or liver disease. Bone-specific alkaline phosphatase (B-ALP) is an isoform of ALP found in the bone tissue which can predict fractures and heterotopic ossification.

objectiveThe aim of this scoping review was to explore the current use of ALP and B-ALP in studies using humans or animal models of SCI, and to identify ways to advance future research using ALP and B-ALP as a bone marker after SCI.

resultsHUMAN STUDIES: 42 studies were included. The evidence regarding changes or differences in ALP levels in individuals with SCI compared to controls is conflicting. For example, a negative correlation between B-ALP and total femur BMD was observed in only one of three studies examining the association. B-ALP seemed to increase after administration of teriparatide, and to decrease after treatment with denosumab. The effects of exercise on ALP and B-ALP levels are heterogeneous and depend on the type of exercise performed. ANIMAL STUDIES: 11 studies were included. There is uncertainty regarding the response of ALP or B-ALP levels after SCI; levels increased after some interventions, including vibration protocols, curcumin supplementation, cycles in electromagnetic field or hyperbaric chamber. Calcitonin or bisphosphonate administration did not affect ALP levels.

conclusionResearchers are encouraged to measure the bone-specific isoform of ALP rather than total ALP in future studies in humans of animal models of SCI.

Indexed as

Bone Density Conservation AgentsSpinal Cord InjuriesAlkaline PhosphataseAnimalsBiomarkersBone and BonesBone DensityBone RemodelingHumansAlkaline PhosphataseBiomarkersBone Density Conservation AgentsBiomarkersBone metabolismPhosphate homeostasisSpinal Injury

Identifiers

PMID34935593
PMCPMC9987745
OpenAlexW4200598651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.