Evidence map›Paper›PMID 34935568›Full record

ArticleAnnals of medicine2022

Clinical impact of Fn-induced high expression of KIR2DL1 in CD8 T lymphocytes in oesophageal squamous cell carcinoma.

Xiaopeng Wang, Yiwen Liu, Yannan Lu, Simo Chen, Yaoping Xing, Haijun Yang, Xiaojun Wang, Yaowen Zhang, Tao Pan, Junkuo Li and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. MedComm · 2025
    Review
  3. Article
  4. Microbial manipulators:Journal of oral microbiology · 2025
    Review
  5. Review
  6. Review
  7. Application ofWorld journal of gastrointestinal oncology · 2024
    Article
  8. Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  9. Article
  10. Expert reviews in molecular medicine · 2023
    Review
  11. Annals of medicine · 2022
    Article
  12. Bioengineering (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Xiaopeng WangAnyang Tumor Hospital (The Fourth Affiliated Hospital of Henan University of Science and Technology), Anyang, Henan, China.
Yiwen LiuCollege of Clinical Medicine, Laboratory of Molecular Biology of the First Affiliated Hospital, Cancer Institute of Henan University of Science and Technology, Henan Key Laboratory of Cancer Epigenetics, Luoyang, Henan, China.
Yannan LuGraduate School of Dalian Medical University, Dalian, Liaoning, China.
Simo ChenThe Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Yaoping XingThe Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Haijun YangAnyang Tumor Hospital (The Fourth Affiliated Hospital of Henan University of Science and Technology), Anyang, Henan, China.
Xiaojun WangBasic Medical School of Henan University of Science and Technology, Luoyang, Henan, China.
Yaowen ZhangAnyang Tumor Hospital (The Fourth Affiliated Hospital of Henan University of Science and Technology), Anyang, Henan, China.
Tao PanDepartment of Lymphoma & Hematology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Junkuo LiAnyang Tumor Hospital (The Fourth Affiliated Hospital of Henan University of Science and Technology), Anyang, Henan, China.
Min WangAnyang Tumor Hospital (The Fourth Affiliated Hospital of Henan University of Science and Technology), Anyang, Henan, China.
Ning ZhangCollege of Clinical Medicine, Laboratory of Molecular Biology of the First Affiliated Hospital, Cancer Institute of Henan University of Science and Technology, Henan Key Laboratory of Cancer Epigenetics, Luoyang, Henan, China.
Mengxia LiangCollege of Clinical Medicine, Laboratory of Molecular Biology of the First Affiliated Hospital, Cancer Institute of Henan University of Science and Technology, Henan Key Laboratory of Cancer Epigenetics, Luoyang, Henan, China.
Fuyou ZhouAnyang Tumor Hospital (The Fourth Affiliated Hospital of Henan University of Science and Technology), Anyang, Henan, China.
Anyang Tumor Hospital · CNHenan Cancer Hospital · CNHenan University of Science and Technology · CNXinxiang Medical University · CNDalian Medical University · CNHunan Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo analyze the correlation between the inducing effect of

methodsThe inducing effect of Fn on CD8

resultsIn the coculture system, KIR2DL1 expression on the surface of CD8

conclusionsLong-term drinking and smoking lead to an extremely unhealthy oral environment in which Fn infection and colonization are more likely to occur, thus inducing high expression of KIR2DL1 on the surface of CD8

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaCD8-Positive T-LymphocytesFusobacterium nucleatumHumansKaplan-Meier EstimateMalePrognosisReceptors, KIR2DL1KIR2DL1 protein, humanReceptors, KIR2DL1CD8+ T lymphocytesFusobacterium nucleatumKIR2DL1oesophageal squamous cell carcinomasprognosis

Identifiers

PMID34935568
PMCPMC8725851
OpenAlexW4200512272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.