Evidence map›Paper›PMID 34935460›Full record

ArticleCannabis and cannabinoid research2022

Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression.

Beth M Wiese, Erika Liktor-Busa, Sarah A Couture, Spyros P Nikas, Lipin Ji, Yingpeng Liu, Alexandros Makriyannis, Igor Spigelman, Todd W Vanderah, Tally M Largent-Milnes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cannabis and cannabinoid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The endocannabinoid system and breathing.Frontiers in neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Beth M WieseDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0003-4111-295X
Erika Liktor-BusaDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Sarah A CoutureDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Spyros P NikasChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Lipin JiChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Yingpeng LiuChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Alexandros MakriyannisChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Igor SpigelmanDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, California, USA.
Todd W VanderahDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Tally M Largent-MilnesDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
University of Arizona · USNortheastern University · USUniversity of California, Los Angeles · US

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EVANS, CHRISTOPHER J. · 1987 to 2021
$30.7M
Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0M
Cannabinoid CB2 Agonists for Treatment of Breast Cancer-Induced Bone PainR01CA142115 · NCI · UNIVERSITY OF ARIZONA · PI VANDERAH, TODD W · 2010 to 2021
$3.3M
New Modalities for the Treatment of Pain and Drug Abuse-Biochemical CoreP01DA041307 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK · 2017 to 2021
$3.0M
Peripherally-restricted cannabinoids for cancer and chemotherapy-induced painR01CA196263 · NCI · NEW YORK UNIVERSITY · PI SCHMIDT, BRIAN L, SPIGELMAN, IGOR · 2016 to 2020
$2.6M
Primary Afferent Transmission in the Trigeminal Dorsal HornF32DE022499 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MILNES, TALLY MARIE · 2011 to 2014
$127k
NCI NIH HHS R01 CA142115NCI NIH HHS R01 CA196263NIDA NIH HHS P01 DA009158NIDA NIH HHS P01 DA041307NIDA NIH HHS P50 DA005010NIDCR NIH HHS F32 DE022499
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CannabinoidsRespiratory InsufficiencyAnalgesics, OpioidBrainCannabinoid Receptor AgonistsEndocannabinoidsHumansMorphineMorpholinesReceptors, CannabinoidAnalgesics, OpioidCannabinoid Receptor AgonistsCannabinoidsEndocannabinoidsMorphineMorpholinesPrNMIReceptors, Cannabinoidcannabinoid receptor 1mu opioid receptoropioid-induced respiratory depressionsynthetic cannabinoid

Identifiers

PMID34935460
PMCPMC9587769
OpenAlexW4200278102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.