ArticleJournal of the American Heart Association2022
Trends in Premature Mortality From Acute Myocardial Infarction in the United States, 1999 to 2019.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The global estimate of premature cardiovascular mortality: a systematic review and meta-analysis of age-standardized mortality rate.BMC public health · 2023Pooled it
- Trial
- Association of systemic inflammation with major adverse cardiovascular events in patients with acute myocardial infarction.American journal of preventive cardiology · 2026Article
- Association of the Triglyceride-Glucose Index with Premature Myocardial Infarction in a Propensity Score-Matched Non-Diabetic Population.Diagnostics (Basel, Switzerland) · 2026Article
- 3D Printable and Electrically Conductive Hyaluronic Acid Hydrogel for Cardiac and Vascular Tissue Engineering Applications.ACS omega · 2026Article
- Predictors of Delayed Hospital Presentation for Myocardial Infarction Among Diabetic Patients: A Retrospective Study.Cureus · 2026Article
- Therapeutic strategies for ischemic heart disease with natural product-based nanomedicines.Journal of nanobiotechnology · 2026Review
- ST-Elevation Myocardial Infarction Complicated by Ventricular Septal Defect Is Associated With Very High Mortality Without Improvement Over Time.Reviews in cardiovascular medicine · 2026Article
- Circulating extracellular microRNAs as tissue-specific biomarkers of human health and disease.Nature communications · 2026Article
- Chaperone-Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Metabolic risk factors associated with premature myocardial infarction in adults ≤ 35 years: a case-control study.BMC cardiovascular disorders · 2026Article
- Disparities in gastrointestinal bleeding and acute myocardial infarction-related mortality in the United States, 1999-2020.Internal and emergency medicine · 2026Article
- Rising Burden of Hypertensive Heart Disease Mortality Among Young Adults in the United States, 1999 to 2024.The American journal of cardiology · 2026Article
- Pharmacologically inherited carbon dots fromTheranostics · 2026Article
- BAK and BAX: Therapeutic Targets for Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury.Biology · 2025Review
- Clinical, economic, and health care resource utilization burden of acute myocardial infarction and the role of systemic inflammation in US hospitals: A real-world study.American journal of preventive cardiology · 2025Article
- Regional and demographic variations in diabetes mellitus and myocardial infarction mortality among US adults: A retrospective observational analysis from 1999 to 2023.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Non-Invasive Diagnosis of Chronic Myocardial Infarction via Composite In-Silico-Human Data Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mortality Trends Associated With Acute Myocardial Infarction and Psychoactive Substance Use in Older Adults: A US Nationwide Analysis (1999-2020).Clinical cardiology · 2025Observational
- The Clinical Significance and Potential of Complex Diagnosis for a Large Scar Area Following Myocardial Infarction.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Evaluating premature (<65 years of age) mortality because of acute myocardial infarction (AMI) by demographic and regional characteristics may inform public health interventions. Methods and Results We used the Centers for Disease Control and Prevention's WONDER (Wide-Ranging Online Data for Epidemiologic Research) death certificate database to examine premature (<65 years of age) age-adjusted AMI mortality rates per 100 000 and average annual percentage change from 1999 to 2019. Overall, the age-adjusted AMI mortality rate was 13.4 (95% CI, 13.3-13.5). Middle-aged adults, men, non-Hispanic Black adults, and rural counties had higher mortality than young adults, women, NH White adults, and urban counties, respectively. Between 1999 and 2019, the age-adjusted AMI mortality rate decreased at an average annual percentage change of -3.4 per year (95% CI, -3.6 to -3.3), with the average annual percentage change showing higher decline in age-adjusted AMI mortality rates among large (-4.2 per year [95% CI, -4.4 to -4.0]), and medium/small metros (-3.3 per year [95% CI, -3.5 to -3.1]) than rural counties (-2.4 per year [95% CI, -2.8 to -1.9]). Age-adjusted AMI mortality rates >90th percentile were distributed in the Southern states, and those with mortality <10th percentile were clustered in the Western and Northeastern states. After an initial decline between 1999 and 2011 (-4.3 per year [95% CI, -4.6 to -4.1]), the average annual percentage change showed deceleration in mortality since 2011 (-2.1 per year [95% CI, -2.4 to -1.8]). These trends were consistent across both sexes, all ethnicities and races, and urban/rural counties. Conclusions During the past 20 years, decline in premature AMI mortality has slowed down in the United States since 2011, with considerable heterogeneity across demographic groups, states, and urbanicity. Systemic efforts are mandated to address cardiovascular health disparities and outcomes among nonelderly adults.
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