Evidence map›Paper›PMID 34935436›Full record

ArticleJournal of virology2022

Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation.

Margarita V Rangel, Nicole McAllister, Kristen Dancel-Manning, Maria G Noval, Laurie A Silva, Kenneth A Stapleford

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Margarita V RangelDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Nicole McAllisterDepartment of Biology, Seton Hill University, Greensburg, Pennsylvania, USA.
Kristen Dancel-ManningMicroscopy Laboratory of Division of Advanced Research Technologies, New York University Langone Medical Centergrid.240324.3, New York, New York, USA.
Maria G NovalDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Laurie A SilvaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kenneth A StaplefordDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-7796-2254
New York University · USUniversity of Pittsburgh · USNYU Langone Health · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aristotelis Tsirigos · 1985 to 2026
$83.1M
INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
Engagement of Glycosaminoglycans during Chikungunya Virus InfectionF31AI147440 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCALLISTER, NICOLE · 2019 to 2020
$85k
HHS | NIH | National Cancer Institute (NCI) P30CA016087NCI NIH HHS P30 CA016087NIAID NIH HHS F31 AI147440NIAID NIH HHS T32 AI007180
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is a reemerging arthropod-borne alphavirus and a serious threat to human health. Therefore, efforts toward elucidating how this virus causes disease and the molecular mechanisms underlying steps of the viral replication cycle are crucial. Using an

Indexed as

Virus AttachmentAedesAnimalsAntibodies, MonoclonalChikungunya FeverChikungunya virusDisease Models, AnimalHeparinHumansInflammationMiceMutationNeutralization TestsViral Envelope ProteinsVirus InternalizationVirus ReplicationAntibodies, MonoclonalE1 envelope protein, Chikungunya virusHeparinViral Envelope ProteinsAlphaviruschikungunya virusemergenceglycoproteininflammation

Identifiers

PMID34935436
PMCPMC8865554
OpenAlexW4220907057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.