Evidence map›Paper›PMID 34935432›Full record

ArticleEnvironmental health perspectives2021

Maternal Phthalates Exposure and Blood Pressure during and after Pregnancy in the PROGRESS Study.

Haotian Wu, Allison Kupsco, Allan Just, Antonia M Calafat, Emily Oken, Joseph M Braun, Alison P Sanders, Adriana Mercado-Garcia, Alejandra Cantoral, Ivan Pantic and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Haotian WuDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID 0000-0002-6271-0249
Allison KupscoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID 0000-0001-8760-2730
Allan JustDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-4312-5957
Antonia M CalafatNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-9796-7482
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-2513-3339
Joseph M BraunDepartment of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA.
Alison P SandersDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8252-4016
Adriana Mercado-GarciaCenter for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico.
Alejandra CantoralCenter for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico.
Ivan PanticDepartment of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.ORCID 0000-0002-3178-1482
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico.ORCID 0000-0003-3322-3334
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Andrea L DeierleinPublic Health Nutrition, School of Global Public Health, New York University, New York, New York, USA.ORCID 0000-0002-2731-4080
Columbia University · USIcahn School of Medicine at Mount Sinai · USInstituto Nacional de Salud Pública · MXBrown University · USCenters for Disease Control and Prevention · USHarvard University · USInstituto Nacional de Perinatología · MXNew York University · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child NeurobehaviorR01ES024381 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2015 to 2018
$2.4M
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) CohortR24ES028522 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Megan K Horton, Maria Jose Rosa · 2017 to 2026
$1.8M
Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal HealthR00ES027508 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANDERS, ALISON P · 2018 to 2020
$738k
Effects of BPA and Phthalates on Adiposity and Metabolic Risk Factors in WomenR00ES023474 · NIEHS · NEW YORK UNIVERSITY · PI DEIERLEIN, ANDREA L · 2015 to 2017
$733k
Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal HealthK99ES027508 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SANDERS, ALISON P · 2017 to 2017
$104k
NIEHS NIH HHS K99 ES027508NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023474NIEHS NIH HHS R00 ES027508NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R01 ES024381NIEHS NIH HHS R24 ES028522
6 · The paper itself

Abstract

backgroundPhthalate exposure is ubiquitous and may affect biological pathways related to regulators of blood pressure. Given the profound changes in vasculature during pregnancy, pregnant women may be particularly susceptible to the potential effects of phthalates on blood pressure.

objectivesWe examined associations of phthalate exposure during pregnancy with maternal blood pressure trajectories from mid-pregnancy through 72 months postpartum.

methodsWomen with singleton pregnancies delivering a live birth in Mexico City were enrolled during the second trimester (

resultsAs a joint mixture, phthalate biomarker concentrations during pregnancy were associated with higher blood pressure rise during mid-to-late gestation. With respect to individual biomarkers, second trimester concentrations of monobenzyl phthalate (MBzP) and di(2-ethylhexyl) phthalate biomarkers ( DISCUSSION: In our cohort of pregnant women from Mexico City, exposure to phthalates and phthalate biomarkers was associated with higher blood pressure during late pregnancy, as well as with long-term changes in blood pressure trajectories. https://doi.org/10.1289/EHP8562.

Indexed as

Environmental PollutantsPhthalic AcidsBayes TheoremBlood PressureEnvironmental ExposureFemaleHumansMaternal ExposurePregnancyEnvironmental Pollutantsphthalic acidPhthalic Acids

Identifiers

PMID34935432
PMCPMC8693773
OpenAlexW4200370008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.