ArticleJournal of the American Heart Association2022
Differential Hemodynamic Response of Pial Arterioles Contributes to a Quadriphasic Cerebral Autoregulation Physiology.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Loss of cerebral autoregulation drives abnormal perfusion patterns after stroke.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Investigating Leptomeningeal Anastomoses' Role in Collateral Blood Flow using SPECT and 4D Flow MRI.Annals of biomedical engineering · 2026Article
- Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation.NPJ digital medicine · 2026Article
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- Evaluation of Cerebral Blood Flow and Cerebral Autoregulation Using Synthetic Data and In Silico Modeling.CNS neuroscience & therapeutics · 2026Article
- Exploring the Upper Limits of Cerebral Perfusion Pressure in Pediatric Traumatic Brain Injury: A STARSHIP Analysis.Neurocritical care · 2026Observational
- First Breath Matters: Out-of-Hospital Mechanical Ventilation in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Article
- Cerebral Resistance Artery Histological Remodeling After Training-Sex Differences.Life (Basel, Switzerland) · 2025Article
- Cerebral autoregulation in traumatic brain injury: looking upwards.Critical care (London, England) · 2025Article
- Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal.Critical care (London, England) · 2025Observational
- Untangling discrepancies between cerebrovascular autoregulation correlation coefficients: An exploration of filters, coherence and power.Physiological reports · 2025Article
- Revisiting the oxygen reactivity index in traumatic brain injury: the complementary value of combined focal and global autoregulation monitoring.Critical care (London, England) · 2025Article
- Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis.PloS one · 2025Article
- Cerebral autoregulation derived blood pressure targets in elective neurosurgery.Journal of clinical monitoring and computing · 2024Article
- Is age or cardiovascular comorbidity the main predictor of reduced cerebrovascular pressure reactivity in older patients with traumatic brain injury?Brain & spine · 2024Article
- Exploration of uncertainty of PRx time trends.Brain & spine · 2024Article
- Red solid line: Patterns of terminal loss of cerebrovascular reactivity at the bedside.Brain & spine · 2024Article
- Continuous monitoring of the lower limit of reactivity in traumatic brain injury patients: understanding what is feasible.Critical care (London, England) · 2023Article
- The pressure reactivity index as a measure of cerebral autoregulation and its application in traumatic brain injury management.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Cerebrovascular autoregulation (CA) regulates cerebral vascular tone to maintain near-constant cerebral blood flow during fluctuations in cerebral perfusion pressure (CPP). Preclinical and clinical research has challenged the classic triphasic pressure-flow relationship, leaving the normal pressure-flow relationship unclear. Methods and Results We used in vivo imaging of the hemodynamic response in pial arterioles to study CA in a porcine closed cranial window model during nonpharmacological blood pressure manipulation. Red blood cell flux was determined in 52 pial arterioles during 10 hypotension and 10 hypertension experiments to describe the pressure-flow relationship. We found a quadriphasic pressure-flow relationship with 4 distinct physiological phases. Smaller arterioles demonstrated greater vasodilation during low CPP when compared with large arterioles (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.