Evidence map›Paper›PMID 34935304›Full record

ArticleCancer medicine2022

Early implementation of a perioperative nutrition support pathway for patients undergoing esophagectomy for esophageal cancer.

Rebecca A Carr, Caitlin Harrington, Christina Stella, Diana Glauner, Erin Kenny, Lianne M Russo, Meghan J Garrity, Manjit S Bains, Smita Sihag, David R Jones and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Post-surgical diets in the ERAS protocol: D-ERAS scoping review.European journal of clinical nutrition · 2026
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rebecca A CarrThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Caitlin HarringtonThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Christina StellaDepartment of Food and Nutrition Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Diana GlaunerDepartment of Food and Nutrition Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Erin KennyDepartment of Food and Nutrition Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Lianne M RussoDepartment of Food and Nutrition Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Meghan J GarrityDepartment of Food and Nutrition Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Manjit S BainsThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Smita SihagThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
David R JonesThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Daniela MolenaThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-1655-4473
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundUnintentional weight loss and malnutrition are associated with poorer prognosis in patients with cancer. Risk of cancer-associated malnutrition is highest among patients with esophageal cancer (EC) and has been repeatedly shown to be an independent risk factor for worse survival in these patients. Implementation of nutrition protocols may reduce postoperative weight loss and enhance recovery in these patients.

methodsWe retrospectively identified all patients who underwent Ivor Lewis esophagectomy for EC from January 2015 to August 2019 from a prospectively collected institutional database. Patients who underwent surgery after the implementation of this protocol (September 2017-August 2019) were compared with patients who underwent resection before protocol implementation (January 2015-July 2017). Patients undergoing surgery during the month of protocol initiation were excluded.

resultsOf the 404 patients included in our study, 217 were in the preprotocol group, and 187 were in the postprotocol group. Compared with the preprotocol group, there were significant reductions in length of hospital stay (p < 0.001), time to diet initiation (p < 0.001), time to feeding tube removal (p = 0.012), and postoperative weight loss (p = 0.002) in the postprotocol group. There was no significant difference in the incidence of postoperative complications, 30-day readmission, or mortality rates between groups.

conclusionsResults of the present study suggest a standardized perioperative nutrition protocol may prevent unintentional weight loss and improve postoperative outcomes in patients with EC undergoing resection.

Indexed as

Esophageal NeoplasmsMalnutritionEsophagectomyHumansPostoperative ComplicationsRetrospective StudiesTreatment OutcomeWeight Losscancer-associated malnutritionesophageal canceresophagectomystandardized nutritional pathwayundernutrition

Identifiers

PMID34935304
PMCPMC8817095
OpenAlexW4200379111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.