Evidence map›Paper›PMID 34935247›Full record

ArticleCancer science2022

FZD10-targeted α-radioimmunotherapy with

Hitomi Sudo, Atsushi B Tsuji, Aya Sugyo, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi

Abstract read
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. LAT1-Targeted Alpha Therapy UsingInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Cure of Disseminated Human Lymphoma with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  16. ACell reports. Medicine · 2023
    Article
  17. Article
  18. HBioconjugate chemistry · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hitomi SudoDepartment of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
Atsushi B TsujiDepartment of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.ORCID https://orcid.org/0000-0003-2726-288X
Aya SugyoDepartment of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
Yosuke HaradaOncoTherapy Science Inc., Kanagawa, Japan.
Satoshi NagayamaDepartment of Surgery, Uji Tokushukai Medical Center, Kyoto, Japan.
Toyomasa KatagiriDivision of Genome Medicine, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID https://orcid.org/0000-0001-5086-7444
Yusuke NakamuraCancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Tatsuya HigashiDepartment of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.

Funding

Japan Society for the Promotion of Science 18H02774Japan Society for the Promotion of Science 21K07230Japan Society for the Promotion of Science 21K07688
6 · The paper itself

Abstract

Synovial sarcomas are rare tumors arising in adolescents and young adults. The prognosis for advanced disease is poor, with an overall survival of 12-18 months. Frizzled homolog 10 (FZD10) is overexpressed in most synovial sarcomas, making it a promising therapeutic target. The results of a phase 1 trial of β-radioimmunotherapy (RIT) with the

Indexed as

ActiniumAlpha ParticlesAnimalsAntibodies, Monoclonal, HumanizedCell Line, TumorFrizzled ReceptorsHumansMiceRadioimmunotherapyRadiotherapy DosageRemission InductionSarcoma, SynovialTissue DistributionTumor BurdenXenograft Model Antitumor AssaysYttrium RadioisotopesActiniumActinium-225Antibodies, Monoclonal, HumanizedFrizzled ReceptorsFZD10 protein, humanYttrium-90Yttrium Radioisotopesbarendsen unitcomplete responsemolecular radiotherapyrelative biological effecttherapeutic nuclear medicine

Identifiers

PMID34935247
PMCPMC8819345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.