Evidence map›Paper›PMID 34934994›Full record

ArticleResuscitation plus2021

One-year outcomes in individual domains of the cerebral performance category extended.

Katharyn L Flickinger, Stephany Jaramillo, Melissa J Repine, Allison C Koller, Margo Holm, Elizabeth Skidmore, Clif Callaway, Jon C Rittenberger

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07002294 (The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07002294 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)

TypeinterventionalSponsorUniversity of PittsburghRan2026 to 2032Enrolled1,618ConditionsCardiac Arrest (CA), Heart Arrest, Heart Arrest, Out-Of-HospitalArmsTransfer to specialty care, Usual care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Katharyn L FlickingerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Stephany JaramilloDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Melissa J RepineDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Allison C KollerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Margo HolmDepartment of Occupational Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences, Pittsburgh, PA, USA.
Elizabeth SkidmoreDepartment of Occupational Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences, Pittsburgh, PA, USA.
Clif CallawayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jon C RittenbergerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · USSUNY Upstate Medical University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical and cognitive impairments are common after cardiac arrest, and recovery varies. This study assessed recovery of individual domains of the Cerebral Performance Category- Extended (CPC-E) 1-year after cardiac arrest. We hypothesized patients would have recovery in all CPC-E domains 1-year after the index cardiac arrest.

methodsProspective cohort study of cardiac arrest survivors evaluating outcome measures mRS, CPC, and CPC-E. Outcomes were assessed at discharge, 3-months, 6-months, and 1-year. We defined recovery of a CPC-E domain when >90% of patients had scores of 1-2 in that domain.

resultsOf 156 patients discharged, 57 completed the CPC-E at discharge, and were included in the analysis. 37 patients had follow-up at 3-months, and 23 patients had follow-up at 6 and 12 months. Only 16 patients had assessments at all four timepoints. Domains of alertness (N = 56, 98%) logical thinking (N = 56; 98%), and attention (N = 55; 96%) recovered by hospital discharge. BADL (N = 34; 92%) and motor skills (N = 36; 97%) recovered by 3-months. Most patients (N = 20; 87%) experienced slight-to-no disability or symptoms (mRS 0-2/CPC 1-2) at 1-year follow up. CPC-E domains of short term memory (78%), mood (87%), fatigue (22%), complex ADL (78%), and return to work (65%) did not recover by 1-year.

conclusionsCPC-E domains of alertness, logical thinking, and attention recover rapidly, while domains of short term memory, mood, fatigue, complex ADL and return to work remain chronically impaired 1-year after cardiac arrest. These deficits are not detected by mRS and CPC. Interventions to improve recovery in these domains are needed.

Indexed as

BADL, Basic Activities of Daily LivingCA, Cardiac ArrestCADL, Complex Activities of Daily LivingCardiac arrestCPC, Cerebral Performance CategoryCPC-E, Cerebral Performance Category ExtendedmRS, Modified Rankin ScaleOutcomePCAC, Post Cardiac Arrest CategoryRecoveryRehabilitation

Identifiers

PMID34934994
PMCPMC8661046
OpenAlexW4200572759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.