ArticleF&S reports2021
Spontaneous ovarian hyperstimulation syndrome in a pregnant woman with hypothyroidism: a case report.
Article in F&S reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Critical ovarian hyperstimulation syndrome leading to severe malnutrition: shedding some lights on an extremely rare case report from Vietnam and narrative review.BMC pregnancy and childbirth · 2026Review
- The clinical diversity of primary hypothyroidism presenting as a spontaneous ovarian hyperstimulation syndrome.Endocrinology, diabetes & metabolism case reports · 2024Article
- Ovarian Hyperstimulation syndrome combined with hypothyroidism: a comprehensive review.Journal of ovarian research · 2024Review
- Aversion of surgical exploration in patients with complex ovarian cysts secondary to overt hypothyroidism: A series of three cases.BMJ case reports · 2024Article
- The Thyroid Hormone Axis and Female Reproduction.International journal of molecular sciences · 2023Review
- Ovarian and intellectual hyperstimulation.F&S reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study a rare case of spontaneous ovarian hyperstimulation syndrome in a naturally conceived pregnancy associated with overt hypothyroidism.
designCase report.
settingEndocrinology private practice. PATIENTS: A 32-year-old woman who was 13 weeks pregnant with bilaterally enlarged ovaries presumed to be secondary to hypothyroidism.
interventionsAdministration of levothyroxine and titration of the dose.
main outcome measuresRegression of signs and symptoms of spontaneous ovarian hyperstimulation syndrome after 12 weeks of therapy.
resultsThe patient was diagnosed with severe hypothyroidism, as confirmed by her elevated thyroid-stimulating hormone level. Ultrasound evaluation revealed ovarian enlargement secondary to multiple contiguous cysts with anechoic content. The patient was administered levothyroxine 175 μg/day. Results of hormonal studies demonstrated thyroid function normality at week 12 after treatment. Incomplete regression of ovarian cysts was also noticed within this period. At week 37, the patient developed preeclampsia, and cesarean delivery was recommended. An 8-month postpartum ultrasound evaluation revealed complete regression of the cysts.
conclusionsSpontaneous ovarian hyperstimulation syndrome secondary to hypothyroidism may be the cause of ovarian enlargement, and levothyroxine replacement seems an appropriate primary therapeutic option. Proper endocrinological assessment of patients is recommended as it may avoid unfavorable outcomes.
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