ArticleF&S reports2021
Infertility treatment and the risk of small for gestational age births: a population-based study in the United States.
Article in F&S reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A large-scale prediction model to predict large for gestational age infants conceived by IVF/ICSI.Frontiers in endocrinology · 2026Article
- Risks of Placental Abruption and Preterm Delivery in Patients Undergoing Assisted Reproduction.JAMA network open · 2024Article
- The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI.Medicina (Kaunas, Lithuania) · 2023Article
- In vitro fertilization as an independent risk factor for perinatal complications: Single-center 10 years cohort study.JBRA assisted reproduction · 2023Article
- Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth.Paediatric and perinatal epidemiology · 2023Article
- Birthweight after assisted reproductive technology: clinical decision-making and patient counseling.F&S reports · 2022Article
- The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution.Frontiers in cell and developmental biology · 2022Review
- Taking a second look at obstetrical outcomes after assisted reproductive technologies.F&S reports · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the association between infertility treatments and small for gestational age (SGA) births.
designCross-sectional study.
settingUnited States, 2015-2019. PATIENTS: Women (n = 16,836,228) who delivered nonmalformed, singleton live births (24-44 weeks' gestation).
interventionsAny infertility treatment, including assisted reproductive technology (ART) and prescribed fertility-enhancing medications.
main outcome measuresSmall for gestational age birth, defined as sex-specific birth weight <10% for gestational age. Associations between SGA and infertility treatment were derived from Poisson regression with robust variance. Risk ratios (RR) and 95% confidence intervals (CI) were derived after adjusting for confounders. In a sensitivity analysis, we corrected for nondifferential exposure misclassification and unmeasured confounding biases.
resultsSubsequently, 1.4% (n = 231,177) of pregnancies resulted from infertility treatments (0.8% ART and 0.6% fertility-enhancing medications). Of these, SGA births occurred in 9.4% (n = 21,771) and 11.9% (n = 1,755,925) of pregnancies conceived with infertility treatment and naturally conceived pregnancies, respectively (adjusted RR, 1.07; 95% CI, 1.06, 1.08). However, after correction for misclassification bias and unmeasured confounding, infertility treatment was associated with a 27% reduced risk of SGA (bias-corrected RR, 0.73; 95% CI, 0.53, 0.85). Similar trends were seen for analyses stratified by exposure to ART and fertility-enhancing medications, as well as for SGA <5th and <3rd percentiles.
conclusionsExposure to infertility treatment is associated with a reduced risk of SGA births. These findings, which are contrary to some published reports, may reflect changes in the modern practice of infertility care, maternal lifestyle, and compliance with prenatal care within the infertile population. Until these findings are corroborated, the associations must be cautiously interpreted.
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