ArticleRadiology. Cardiothoracic imaging2021
Prevalence of Venovenous Shunting and High-Output State Quantified with 4D Flow MRI in Patients with Fontan Circulation.
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Article in Radiology. Cardiothoracic imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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8 citing papers in PubMed, 17 citations in OpenAlex.
- AI Applied to Cardiac Magnetic Resonance for Precision Medicine in Coronary Artery Disease: A Systematic Review.Journal of cardiovascular development and disease · 2025Review
- Four-Dimensional Flow in Fontan Patients: Advanced Haemodynamic Assessment.Journal of clinical medicine · 2025Review
- Impact of 4D-Flow CMR Parameters on Functional Evaluation of Fontan Circulation.Pediatric cardiology · 2024Article
- Percutaneous closure of veno-venous collaterals in adult patients with univentricular physiology after Fontan palliation: Single centre experience and systematic review.International journal of cardiology. Congenital heart disease · 2023Article
- Transforming breast reconstruction: the pioneering role of artificial intelligence in preoperative planning.Gland surgery · 2023Article
- 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Review
- Review
- Collaterals in congenital heart disease: when and how to treat?Cardiovascular diagnosis and therapy · 2023Review
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Authors and funding
11 authors at 1 institution in 5 countries.
Francesca RaimondiUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.ORCID https://orcid.org/0000-0003-2580-151X
Duarte MartinsUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.ORCID 0000-0003-0662-5629
Raluca CoenenUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.ORCID 0000-0003-2338-1240
Elena PanaioliUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.
Diala KhraicheUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.
Nathalie BoddaertUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.
Damien BonnetUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.ORCID 0000-0002-8722-5805
Melany AtkinsUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.
Howaida El-SaidUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.ORCID 0000-0002-3447-7398
Laith AlshawabkehUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.
Albert HsiaoUnité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence des Maladies Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., D.K., D.B.); Pediatric Radiology Unit, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France (F.R., E.P., N.B.); Decision and Bayesian Computation, Computation Biology Department, CNRS, URS 3756, Neuroscience Department, CNRS UMR 3571, Institut Pasteur, Paris, France (F.R.); School of Biomedical Engineering & Imaging Sciences, King's College London, Lambeth Wing, St Thomas' Hospital, London, England (F.R.); Department of Pediatric Cardiology, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal (D.M.); Radiology and Cardiology Unit, Erasmus MC, Rotterdam, the Netherlands (R.C.); Fairfax Radiological Consultants, Fairfax, Va (M.A.); and Departments of Pediatric Cardiology (H.E.S.), Cardiovascular Medicine (L.A.), and Radiology (A.H.), University of California, San Diego, 9300 Campus Point Dr, Room 7756, La Jolla, CA 92037-7756.ORCID https://orcid.org/0000-0002-9412-1369
Hôpital Necker-Enfants Malades · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the ability of four-dimensional (4D) flow MRI to quantify flow volume of the Fontan circuit, including the frequency and hemodynamic contribution of systemic-to-pulmonary venovenous collateral vessels. MATERIALS AND
methodsIn this retrospective study, patients with Fontan circulation were included from three institutions (2017-2021). Flow measurements were performed at several locations along the circuit by two readers, and collateral shunt volumes were quantified. The frequency of venovenous collaterals and structural defects were tabulated from concurrent MR angiography, contemporaneous CT, or catheter angiography and related to Fontan clinical status. Statistical analysis included Pearson and Spearman correlation and Bland-Altman analysis.
resultsSeventy-five patients (mean age, 20 years; range, 5-58 years; 46 female and 29 male patients) were included. Interobserver agreement was high for aortic output, pulmonary arteries, pulmonary veins, superior vena cava (Glenn shunt), and inferior vena cava (Fontan conduit) (range, ρ = 0.913-0.975). Calculated shunt volume also showed strong agreement, on the basis of the difference between aortic and pulmonary flow (ρ = 0.935). A total of 37 of 75 (49%) of the patients exhibited shunts exceeding 1.00 L/min, 81% (30 of 37) of whom had pulmonary venous or atrial flow volume step-ups and corresponding venovenous collaterals. A total of 12% of patients (nine of 75) exhibited a high-output state (>4 L/min/m
conclusionFontan flow and venovenous shunting can be reliably quantified at 4D flow MRI; high-output states were found in a higher proportion of patients than expected, among whom venovenous collaterals were common and constituted a substantial proportion of cardiac output.
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CardiacCongenitalHemodynamics/Flow DynamicsMR AngiographyPediatricsTechnology Assessment
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