ArticleEClinicalMedicine2022
Measurement of glomerular filtration rate using endogenous d-serine clearance in living kidney transplant donors and recipients.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Application of Analytical Techniques to Chiral Amino Acid Profiling in Clinical Samples: Bridging Chemistry and Disease Research.Chirality · 2026Review
- Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.APL bioengineering · 2026Review
- Sources and Metabolism of D-Amino Acids and Their Roles as Biomarkers in Kidney Disease: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate.Chemistry & biodiversity · 2025Review
- Detection of Fast Decliner of Diabetic Kidney Disease Using Chiral Amino Acid Profiling: A Pilot Study.Chemistry & biodiversity · 2025Article
- d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection.Chembiochem : a European journal of chemical biology · 2025Review
- Kinetic analysis of D-Alanine upon oral intake in humans.Amino acids · 2024Article
- Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects.Translational psychiatry · 2024Article
- D-Serine as a sensor and effector of the kidney.Clinical and experimental nephrology · 2023Review
- Blood levels of d-amino acids reflect the clinical course of COVID-19.Biochemistry and biophysics reports · 2023Article
- D-Asparagine is an Ideal Endogenous Molecule for Measuring the Glomerular Filtration Rate.Kidney international reports · 2023Article
- Detection and analysis of chiral molecules as disease biomarkers.Nature reviews. Chemistry · 2023Review
- d-Alanine as a biomarker and a therapeutic option for severe influenza virus infection and COVID-19.Biochimica et biophysica acta. Molecular basis of disease · 2023Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndogenous molecules that provide an unbiased and a precise evaluation of kidney function are still necessary. We explored the potential of clearance of d-serine, a rare enantiomer of serine and a biomarker of kidney function, as a measure of glomerular filtration rate (GFR).
methodsThis was a cross-sectional observational study of 200 living kidney transplant donors and recipients enrolled between July 2019 and December 2020 in a single Japanese center, for whom GFR was measured by clearance of inulin (C-in). Clearance of d-serine (C-dSer) was calculated based on blood and urine levels of d-serine, as measured by two-dimensional high-performance liquid chromatography. Analytical performance was assessed by calculating biases. Utilizing data from 129 participants, we developed equations for C-in based on C-dSer and C-cre using a linear regression model, and the performance was validated in 68 participants.
findingsThe means of C-in and C-dSer were 66.7 and 55.7 mL/min/1.73 m
interpretationThe smaller proportional bias compared to that of C-cre is an advantage of C-dSer as a measure of C-in. Combinational measurement of d-serine and creatinine, two endogenous molecules, has the potential to serve as a measure of GFR with precision and minor biases and can support important clinical decisions.
fundingJapan Society for the Promotion of Science (JSPS, grant number 17H04188), Japan Agency of Medical Research and Development (AMED, JP20gm5010001), Osaka Kidney Bank (OKF19-0010), Shiseido Co., Ltd and KAGAMI Inc.
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