Evidence map›Paper›PMID 34934923›Full record

ArticleiScience2021

Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS.

Eleonora D'Ambra, Tiziana Santini, Erika Vitiello, Sara D'Uva, Valentina Silenzi, Mariangela Morlando, Irene Bozzoni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Eleonora D'AmbraDepartment of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Tiziana SantiniDepartment of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Erika VitielloDepartment of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Sara D'UvaDepartment of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Valentina SilenziDepartment of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Mariangela MorlandoDepartment of Pharmaceutical Sciences, "Department of Excellence 2018-2022", University of Perugia, Perugia, Italy.
Irene BozzoniDepartment of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITItalian Institute of Technology · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CircRNAs belong to a family of RNA molecules which are conserved in evolution, have tissue-specific expression, and are abundant in neuronal cells. Here, we define several features of circ-Hdgfrp3 and describe interesting alterations occurring in motor neurons (MNs) carrying ALS-associated FUS mutations. Through a highly sensitive

Indexed as

Biological sciencesCellular neuroscienceMolecular neuroscience

Identifiers

PMID34934923
PMCPMC8661529
OpenAlexW3214969196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.