ArticleResearch and practice in thrombosis and haemostasis2021
Thrombo-inflammatory biomarkers and D-dimer in a biracial cohort study.
Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04505774 (A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults With COVID-19), which is not on this map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults With COVID-19
Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Influence of Coagulation Factor VIII on Ischemic Stroke.Revista de neurologia · 2026Observational
- Early prediction of plastic bronchitis in pediatric patients withFrontiers in cellular and infection microbiology · 2026Article
- Preoperative D‑dimer level and prognosis in patients diagnosed with gastric cancer and undergoing gastric cancer radical surgery: A retrospective cohort study.Oncology letters · 2025Article
- Article
- Social determinants of health in pulmonary embolism management and outcome in hospitals: Insights from the United States nationwide inpatient sample.Research and practice in thrombosis and haemostasis · 2023Article
- D-dimer and the risk of hypertension: The REasons for Geographic And Racial Differences in Stroke Cohort Study.Research and practice in thrombosis and haemostasis · 2023Article
- Increased plasma D-dimer levels may be a promising indicator for diabetic peripheral neuropathy in type 2 diabetes.Frontiers in endocrinology · 2022Article
- Thrombo-inflammatory biomarkers and D-dimer in a biracial cohort study.Research and practice in thrombosis and haemostasis · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHigher D-dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D-dimer and other thrombo-inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people.
objectiveTo assess whether Black individuals have an exaggerated correlation between D-dimer and thrombo-inflammatory biomarkers characteristic of cardiovascular diseases.
methodsLinear regression was used to assess correlations of 11 thrombo-inflammatory biomarkers with D-dimer in a cross-sectional study of 1068 participants of the biracial Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.
resultsAdverse levels of most biomarkers, especially fibrinogen, factor VIII, C-reactive protein, N-terminal pro-B-type natriuretic peptide, and interleukin (IL)-6, were associated with higher D-dimer. Several associations with D-dimer differed significantly by race. For example, the association of factor VIII with D-dimer was more than twice as large in Black compared to White participants. Specifically, D-dimer was 26% higher per standard deviation (SD) higher factor VIII in Black adults and was only 11% higher per SD higher factor VIII in White adults. In Black but not White adults, higher IL-10 and soluble CD14 were associated with higher D-dimer.
conclusionsFindings suggest that D-dimer might relate to Black/White differences in cardiovascular diseases and venous thromboembolism because it is a marker of amplified thrombo-inflammatory response in Black people. Better understanding of contributors to higher D-dimer in the general population is needed.
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Registered trials
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