ArticleAdvances in radiation oncology
Assessing the Spleen as an Organ at Risk in Radiation Therapy and Its Relationship With Radiation-Induced Lymphopenia: A Retrospective Study and Literature Review.
Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Response-adapted ultra-low-dose 4 Gy radiation as definitive therapy of gastric MALT lymphoma: a single-centre, pilot trial.The Lancet. Haematology · 2024Trial
- Transitioning from CA to NCAPhysical and engineering sciences in medicine · 2026Article
- Radiation induced lymphopenia during PRRT: Incidence, course, predictive factors, and association with overall survival.European journal of nuclear medicine and molecular imaging · 2026Article
- Comparative Dosimetric Analysis of Jaw Tracking Versus Non-Jaw Tracking Techniques in Head and Neck and Brain Cancers: A Systematic Review and Meta-Analysis.Advanced biomedical research · 2026Review
- Radiation-induced lymphopenia: A data compilation to unveil relevant factors and mitigation strategies.Clinical and translational radiation oncology · 2026Review
- Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation-Induced Lymphopenia.Cancer medicine · 2026Article
- Advances in Vaccine-Based Therapies for Pancreatic Cancer.Journal of gastrointestinal cancer · 2025Review
- Platelet-to-albumin ratio and radiation-induced lymphopenia-prognostic biomarker for carcinoma esophagus.Journal of the Egyptian National Cancer Institute · 2024Article
- Whole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics.Journal of cancer research and clinical oncology · 2023Article
- Predicting Severity of Radiation Induced Lymphopenia in Individual Proton Therapy Patients for Varying Dose Rate and Fractionation Using Dynamic 4-Dimensional Blood Flow Simulations.International journal of radiation oncology, biology, physics · 2023Article
- Neoadjuvant chemoradiotherapy induced lymphopenia in gastric cancer and associations with spleen dosimetry and survival outcomes.Clinical and translational radiation oncology · 2023Article
- Characterization and Efficacy of a Nanomedical Radiopharmaceutical for Cancer Treatment.ACS omega · 2023Article
- Radiation-induced lymphopenia does not impact treatment efficacy in a mouse tumor model.Neoplasia (New York, N.Y.) · 2022Article
- Review
- Blood Group Type Association with Head and Neck Cancer.Hematology reports · 2022Article
- Article
- Radiation response of soft-tissue extramedullary plasmacytoma in multiple myeloma-A case report.Clinical case reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe conducted a systematic review and a retrospective study to investigate the relationship between spleen irradiation and lymphocyte toxicity. METHODS AND MATERIALS: Forty-six patients diagnosed with locally advanced gastric, esophageal, and pancreatic cancer who underwent radiation therapy were included in this study. The spleen was contoured for each patient. Volumes that received 5 up to 40 Gy (5 Gy increments), minimum, mean, and maximum dose were considered along with lymphocyte count to determine toxicity. Comprehensive and systematic literature searches were performed using PubMed, SCOPUS, Cochrane Central Databases, and Google Scholar.
resultsLiterature review on spleen unintended irradiation and lymphocyte toxicity resulted in 408 patients from 5 studies. In our study, univariate and multivariate linear regressions found an association between V15 (chemotherapy as controlling factor) and nadir lymphocyte count (
conclusionsAlthough there is no consensus regarding lymphopenia spleen dose volume threshold, all studies found that higher splenic dose increases the risk of lymphopenia. Our study's results suggest that spleen unintentional V15 and maximum dose irradiation were associated with lymphopenia during chemoradiation therapy.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.