Evidence map›Paper›PMID 34934823›Full record

ArticleJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)2021

The Use of Hydroxyurea in the Treatment of COVID-19.

Melissa Robin Bowman Foster, Ali Atef Hijazi, Rebecca Opoku, Priya Varghese, Chun Li

Abstract read
In one paragraph

Article in Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melissa Robin Bowman FosterWinston-Salem State University, Winston-Salem, NC, USA.
Ali Atef HijaziWinston-Salem State University, Winston-Salem, NC, USA.
Rebecca OpokuWinston-Salem State University, Winston-Salem, NC, USA.
Priya VargheseWinston-Salem State University, Winston-Salem, NC, USA.
Chun LiWinston-Salem State University, Winston-Salem, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe rapid worldwide spread of COVID-19 motivated medical professionals to pursue and authenticate appropriate remedies and treatment protocols. This article aims to analyze the potential benefits of one treatment protocol developed by a group of care providers caring for severe COVID-19 patients.

methodsThe clinical findings of COVID-19 patients who were transferred to a specialized care hospital after unsuccessful treatment in previous institutions, were analyzed. The specialized care hospital used a treatment protocol including hydroxyurea, a medication commonly used for sickle cell treatment, to improve respiratory distress in the COVID-19 patients. None of the COVID-19 patients included in the analyzed data were diagnosed with sickle cell, and none had previously taken hydroxyurea for any other conditions.

resultsIn all presented cases, patients reverted to their baseline respiratory health after treatment with the hydroxyurea protocol. There was no significant difference in the correlation between COVID-19 and hydroxyurea. However, deaths were extremely low for those taking hydroxyurea.

conclusionsFatality numbers were extremely low for those taking hydroxyurea; death could be attributed to other underlying issues.

Indexed as

COVID-19critical respiratory carehydroxyureatreatment

Identifiers

PMID34934823
PMCPMC8647674

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.