Evidence map›Paper›PMID 34934798›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds.

Tahzeeb Fatima, Lennart T H Jacobsson, Silke Kern, Anna Zettergren, Kaj Blennow, Henrik Zetterberg, Lena Johansson, Mats Dehlin, Ingmar Skoog

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Pathway for ascertaining the role of uric acid in neurodegenerative diseases.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tahzeeb FatimaDepartment of Rheumatology and Inflammation Research Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.ORCID https://orcid.org/0000-0002-6082-2853
Lennart T H JacobssonDepartment of Rheumatology and Inflammation Research Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Silke KernDepartment of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Anna ZettergrenDepartment of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Lena JohanssonDepartment of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Mats DehlinDepartment of Rheumatology and Inflammation Research Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Ingmar SkoogDepartment of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
University of Gothenburg · SESahlgrenska University Hospital · SELund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated.

methodsWe examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)

resultsSerum urate was positively associated with Aβ DISCUSSION: The positive association between urate and Aβ

Indexed as

Alzheimer's diseaseapolipoprotein E ε4cerebrospinal fluid biomarkersdementiaurate

Identifiers

PMID34934798
PMCPMC8652407
OpenAlexW4205324988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.