Transcriptomic analysis of synchrony and productivity in self-cycling fermentation of engineered yeast producing shikimic acid.

Yusheng Tan, Roman Vincent C Agustin, Lisa Y Stein, Dominic Sauvageau

Open access · goldAbstract read

In one paragraph

Article in Biotechnology reports (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.4field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

High-cell density two-stage self-cycling fermentation system for the enhanced production of ethanol from steam-exploded poplar hydrolysate.Bioresources and bioprocessing · 2026
Article
Biphasic Metabolic Control of Shikimic Acid Production inACS omega · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yusheng TanDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.

Roman Vincent C AgustinDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.

Lisa Y SteinDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

Dominic SauvageauDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.

University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Industrial fermentation provides a wide variety of bioproducts, such as food, biofuels and pharmaceuticals. Self-cycling fermentation (SCF), an advanced automated semi-continuous fermentation approach, has shown significant advantages over batch reactors (BR); including cell synchrony and improved production. Here,

Indexed as

BR, Batch reactorcDNA, Complementary deoxyribonucleic acidCER, Carbon dioxide evolution rateDDT, DithiothreitolDNA, Deoxyribonucleic acidEDTA, Ethylenediaminetetraacetic acidFC, Fold changemRNA, Messenger ribonucleic acidOD600, Optical density at 600 nmqPCR, Quantitative polymerase chain reactionRNA, Ribonucleic acidSaccharomyces cerevisiaeSCF, Self-cycling fermentationSelf-cycling fermentation (SCF)Shikimic acidSTP, Standard temperature and pressureSynchronyTranscriptomics

Identifiers

PMID34934640

DOI10.1016/j.btre.2021.e00691

PMCPMC8660916

OpenAlexW4200167894

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.