Evidence map›Paper›PMID 34934493›Full record

ArticleClinical case reports2021

Lichen planus flare following COVID-19 vaccination: A case report.

Astrid Herzum, Martina Burlando, Mattia F Molle, Claudia Micalizzi, Emanuele Cozzani, Aurora Parodi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Lichen planus after COVID-19 infection and vaccination.Archives of dermatological research · 2023
    Review
  5. Article
  6. Comprehensive Insight into Lichen Planus Immunopathogenesis.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. New-onset vitiligo following COVID-19 disease.Skin health and disease · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature.Clinical, cosmetic and investigational dermatology · 2022
    Review
  15. New-Onset Lichen Planus Induced by the Pfizer COVID-19 Vaccine.Case reports in dermatological medicine · 2022
    Article
  16. Article
  17. Lichen striatus after COVID-19.Clinics in dermatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Astrid HerzumDepartment of Dermatology Di.S.Sal San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.ORCID https://orcid.org/0000-0001-6373-8801
Martina BurlandoDepartment of Dermatology Di.S.Sal San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.
Mattia F MolleDepartment of Dermatology Di.S.Sal San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.
Claudia MicalizziDepartment of Dermatology Di.S.Sal San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.
Emanuele CozzaniDepartment of Dermatology Di.S.Sal San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.
Aurora ParodiDepartment of Dermatology Di.S.Sal San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.
Ospedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the third case of cutaneous lichen planus (LP) following COVID-19 BNT162b2 vaccination in a 59-year-old woman with previous LP. The reactivation of LP in patients with dormant LP suggests a possible vaccine-induced immune dysregulation. We suggest that the already described vaccine-induced upregulation of Th1 response may play a relevant role in LP reactivation, through an increase in inflammatory cytokines involved in the pathogenesis of LP. Interestingly, LP has already been associated with vaccinations and viral infections including COVID-19 disease. However, the exact mechanism underlying LP (re)activation after Pfizer-BiotNtech COVID-19 vaccination is still widely unknown and needs to be further investigated.

Indexed as

COVID‐19 cutaneousCOVID‐19 skinCOVID‐19 vaccinationCOVID‐19 vaccinelichen planus

Identifiers

PMID34934493
PMCPMC8650756
OpenAlexW4200063118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.