Evidence map›Paper›PMID 34934406›Full record

ArticleMolecular imaging2021

PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to

Hao Jiang, Jiwei Gu, Haiyang Zhao, Sumit Joshi, Joel S Perlmutter, Robert J Gropler, Robyn S Klein, Tammie L S Benzinger, Zhude Tu

Open access · goldAbstract read
In one paragraph

Article in Molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
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  4. Evaluation of [AJNR. American journal of neuroradiology · 2026
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  8. Review
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  14. Radiosynthesis and evaluation of a fluorine-18 radiotracer [Organic & biomolecular chemistry · 2022
    Article
  15. Review
  16. Article
  17. Characterization of a S1PR2 specificNuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Hao JiangDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-8845-4378
Jiwei GuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-4908-7544
Haiyang ZhaoDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0003-1775-3538
Sumit JoshiDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0001-7039-4787
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0003-3263-8917
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-6550-0570
Robyn S KleinDepartment of Neuroscience, Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0003-0281-1352
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-8114-0552
Zhude TuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0003-0325-835X
Saint Louis University · ES

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
NIBIB NIH HHS P41 EB025815NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS107281
6 · The paper itself

Abstract

Sphingosine-1-phosphate receptor 1 (S1PR1) plays a crucial role in infectious diseases. Targeting S1PR1 provides protection against pathogens, such as influenza viruses. This study is aimed at investigating S1PR1 in response to bacterial infection by assessing S1PR1 expression in

Indexed as

Communicable DiseasesMethicillin-Resistant Staphylococcus aureusAnimalsMicePositron-Emission TomographyPositron Emission Tomography Computed TomographySphingosine-1-Phosphate ReceptorsStaphylococcus aureusTissue DistributionSphingosine-1-Phosphate Receptors

Identifiers

PMID34934406
PMCPMC8654346
OpenAlexW3203688274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.