Evidence map›Paper›PMID 34934400›Full record

ReviewReproductive medicine and biology2022

Kisspeptin neurons as an integration center of reproductive regulation: Observation of reproductive function based on a new concept of reproductive regulatory nervous system.

Hitoshi Ozawa

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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  15. Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hitoshi OzawaDepartment of Anatomy and Neurobiology Graduate School of Medicine Nippon Medical School Tokyo Japan.ORCID https://orcid.org/0000-0003-2534-5913
Nippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRegulation of the reproductive system has been explained by the actions and feedback of gonadotropin releasing hormone-luteinizing hormone/follicle stimulating hormone (GnRH-LH/FSH) -sex steroids; however, the discovery of kisspeptin neurons and a kisspeptin-GnRH-LH/FSH axis has prompted this regulation to be reviewed.

methodsWe investigated changes in kisspeptin neurons and associated changes in the hypothalamic-pituitary-gonadal (HPG) axis under various situations and experimental conditions using histochemical methods. MAIN FINDINGS

resultsKisspeptin neurons play an important role in receiving and integrating information from internal and external environmental factors and communicating it to the conventional HPG axis.

conclusionThe recently described Kisspeptin-GnRH-LH/FSH-gonad system regulates reproductive function via mechanisms that until recently were not completely understood.

Indexed as

gonadotropin‐releasing hormoneHPG axiskisspeptinpubertyreproductive regulation

Identifiers

PMID34934400
PMCPMC8656200
OpenAlexW3206639248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.