Evidence map›Paper›PMID 34934314›Full record

ArticleInternational journal of nanomedicine2021

Regulatory Effects of Damaged Renal Epithelial Cells After Repair by

Xin-Yuan Sun, Hui Zhang, Ji-Wang Deng, Bang-Xian Yu, Yi-Han Zhang, Jian-Ming Ouyang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Neuroprotective Mechanisms ofMarine drugs · 2025
    Review
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  5. SulfatedAntioxidants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xin-Yuan Sun *Department of Urology, Guangzhou Institute of Urology, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510230, People's Republic of China.ORCID 0000-0002-8929-1099
Hui Zhang *Department of Chemistry, Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, 510632, People's Republic of China.
Ji-Wang Deng *Department of Urology, Guangzhou Institute of Urology, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510230, People's Republic of China.
Bang-Xian YuDepartment of Urology, Guangzhou Institute of Urology, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510230, People's Republic of China.
Yi-Han ZhangDepartment of Urology, Guangzhou Institute of Urology, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510230, People's Republic of China.
Jian-Ming OuyangDepartment of Chemistry, Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, 510632, People's Republic of China.ORCID 0000-0001-8075-3915
First Affiliated Hospital of Guangzhou Medical University · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interaction between urinary microcrystals and renal epithelial cells is closely related to kidney stone formation. However, the mechanism of cell state changes that affect crystal-cell interaction remains unclear.

methodsThis study investigated the relationship between the sulfate group (-OSO

resultsAfter repair by PYPs, the cell viability increased, the number of reactive oxygen species decreased, and the reduction of mitochondrial membrane potential and the release of intracellular Ca

conclusionSPYP2 showed the best ability to repair damaged cells, followed by SPYP1 and PYP. SPYP2 may become a potential green drug that inhibits the formation and recurrence of calcium oxalate stones.

Indexed as

Calcium OxalatePorphyraCell CommunicationCell LineEpithelial CellsHumansPolysaccharidesCalcium OxalatePolysaccharidesadhesion and endocytosiscell repairkidney stonepolysaccharide sulfationPorphyra yezoensis polysaccharide

Identifiers

PMID34934314
PMCPMC8684390
OpenAlexW4200154688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.