Evidence map›Paper›PMID 34934310›Full record

ArticleClinical interventions in aging2021

The Effect of Daily Teriparatide versus One-Time Annually Zoledronic Acid Administration After Transforaminal Lumbar Interbody Fusion in Osteoporotic Patients.

Zixiang Wang, Chenyang Zhuang, Weisin Chen, Zefang Li, Juan Li, Hong Lin, Jian Dong

Open access · goldAbstract read
In one paragraph

Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Timing of osteoporosis therapies following fracture: the current status.Therapeutic advances in endocrinology and metabolism · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zixiang Wang *Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Chenyang Zhuang *Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Weisin ChenDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Zefang LiDepartment of Orthopedics, Qianjiang Central Hospital of Chongqing, Chongqing, 409000, People's Republic of China.
Juan LiDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Hong LinDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Jian DongDepartment of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
The First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CNFudan University · CNQianjiang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe research aimed to compare the therapeutic effect of teriparatide (TPTD) and zoledronic acid (ZOL) therapy on bone formation and spinal fusion in patients with osteoporosis (OP) who underwent transforaminal lumbar interbody fusion (TLIF).

methodsOn the basis of different anti-OP treatment options, the TPTD group was treated daily with TPTD (20 μg. ih. qd) for at least 6 months, while the ZOL group was treated with a single dose of ZOL (5 mg. ivgtt. st) postoperatively. The visual analogue scale (VAS), Oswestry Disability Index (ODI), bone mineral density (BMD), and concentration of bone turnover markers before, 6, and 12 months after surgery were evaluated. X-ray and three-dimensional computed tomography scans were performed at 6 and 12 months postoperatively to assess interbody fusion.

resultsThe number of patients in the TPTD and ZOL groups was 29 and 38 patients, respectively. The VAS and ODI scores in both groups were significantly reduced at 6 and 12 months after TLIF. Compared with that of baseline, the lumbar spine BMD of TPTD patients increased significantly from 0.716±0.137 g/cm

conclusionTPTD was more efficient than ZOL in bone formation and spinal fusion in OP patients who underwent TLIF.

Indexed as

Bone Density Conservation AgentsSpinal FusionTeriparatideZoledronic AcidHumansLumbar VertebraeOsteoporosisRetrospective StudiesTreatment OutcomeBone Density Conservation AgentsTeriparatideZoledronic AcidosteoporosisteriparatideTLIFzoledronic acid

Identifiers

PMID34934310
PMCPMC8678629
OpenAlexW3202946289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.