Evidence map›Paper›PMID 34934271›Full record

ArticleInternational journal of clinical pediatric dentistry

Efficacy of Cryotherapy Application on the Pain Perception during Intraoral Injection: A Randomized Controlled Trial.

Lakshimi Lakshmanan, Vignesh Ravindran

2 registry-linked trialsOpen access · diamondAbstract read
In one paragraph

Article in International journal of clinical pediatric dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06011005 naunknown statusnot on this map

Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel- a Single-blinded Randomized Controlled Trial.

TypeinterventionalSponsorMohammed Bin Rashid University of Medicine and Health SciencesRan2023 to 2023Enrolled42ConditionsDental Caries in Children, Anesthesia, Local, Injection Site DiscomfortArmsEthyl Chloride spray (group A), Benzocaine gel 20% (group B)
NCT07198022 phase4completednot on this map

Comparative Evaluation of Application of Topical Anesthetic Gel, Solution and Cryotherapy

TypeinterventionalSponsorOndokuz Mayıs UniversityRan2025 to 2026Enrolled100ConditionsHealthy, Topical Anesthesia, Pediatric Dentistry, CryotherapyArmsCryotherapy, topical anesthetic, Topical anesthetic gel
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Effect of cryoanaesthesia on pain during intraoral anaesthetic puncture in children: a randomised controlled non-inferiority trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lakshimi LakshmananDepartment of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India.
Vignesh RavindranDepartment of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India.
Saveetha University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProfound local anesthetic delivery promotes successful treatment for children in terms of easing their fear, anxiety, and discomfort during dental procedures. Local anesthetic injections are the utmost anticipated or anxious stimuli in the dental operatory. Precooling the oral mucosa by application of cryotherapy before local anesthetic injections can alter the pain perception in children. AIM AND

objectivesTo compare the efficacy of cryotherapy application and 20% benzocaine gel at reducing pain perception during buccal infiltration in pediatric patients. MATERIALS AND

methodsIn this split-mouth study, 30 pediatric patients between 7 years and 10 years of age who needed maxillary buccal infiltration of local anesthetics bilaterally for dental treatment were selected. They received cryotherapy (ice pack) on one quadrant (test group) for 2 minutes and 20% benzocaine topical gel on the contralateral quadrant (control group). A pediatric dentist blinded to the study assessed sound, eye, motor (SEM) scale based on patients' reaction during injection (objective method), and patients were instructed to use a visual analog scale (VAS) to rate their distress during injection (subjective method). Statistical analyses were performed using Wilcoxon and Mann-Whitney

resultsThe cryotherapy group had significantly reduced pain scores on the VAS scale (40.66 ± 14.60) when compared with the topical anesthetic gel group (61.33 ± 9.73). The cryotherapy group had reduced pain scores on the SEM scale as well (1.2 ± 0.1) when compared with the topical anesthetic gel group (1.6 ± 0.1), which was not statistically significant.

conclusionWhen compared with topical anesthetic gel, precooling the injection site with cryotherapy is beneficial in reducing pain before local anesthesia injection in pediatric patients. CLINICAL SIGNIFICANCE: Cryotherapy application eliminates the fear of pain ascribed to injection of local anesthesia and assists in providing pertinent dental care. HOW TO CITE THIS ARTICLE: Lakshmanan L, Ravindran V. Efficacy of Cryotherapy Application on the Pain Perception during Intraoral Injection: A Randomized Controlled Trial 2021;14(5):616-620.

Indexed as

CryotherapyLocal anesthesia injectionPainTopical anesthesia

Identifiers

PMID34934271
PMCPMC8645627
OpenAlexW3216177015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.