ArticleInternational journal of clinical pediatric dentistry
Efficacy of Cryotherapy Application on the Pain Perception during Intraoral Injection: A Randomized Controlled Trial.
Article in International journal of clinical pediatric dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel- a Single-blinded Randomized Controlled Trial.
Comparative Evaluation of Application of Topical Anesthetic Gel, Solution and Cryotherapy
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of cryoanaesthesia on pain during intraoral anaesthetic puncture in children: a randomised controlled non-inferiority trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Comparative Evaluation of the Effectiveness of Intrapulpal Crushed Ice and Intrapulpal Local Anesthesia during Pulpectomy in Primary Molars.International journal of clinical pediatric dentistry · 2026Article
- Comparative Evaluation of Pain Perception and Postoperative Pain in Children with Precooled Injection Sites Using Popsicles for Local Anesthesia: A Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2026Article
- Efficacy of ethyl chloride topical anesthesia application on pain perception during intra-oral injections in children compared to benzocaine gel-a single-blind randomized controlled trial.Frontiers in dental medicine · 2026Article
- A Comparative Study on Pain Perception in Children, After Application of Pre-Cooled and Plain Topical Anaesthetic Gel During Local Anaesthetic Administration-A Parallel Three-Arm Randomised Control Trial.Children (Basel, Switzerland) · 2025Article
- The effect of temperature of sodium hypochlorite on fracture resistance of endodontically treated teeth - AnJournal of conservative dentistry and endodontics · 2025Article
- Role of Pharmacology in Dentistry: A Review of Analgesics, Antibiotics, and Local Anesthetics.Cureus · 2025Review
- The efficacy of sweet solutions on dental injection related pain: a systematic review of randomized controlled trials.Journal of dental anesthesia and pain medicine · 2025Review
- Topical anesthetics methods used to reduce needle pain/discomfort prior to local anesthesia in children and adolescents: a scoping review.Evidence-based dentistry · 2025Article
- Effect of precooling on the assessment of pain during local anesthesia in adults: A systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
- Comparative Evaluation of Effectiveness of Benzocaine Gel and Ice for Pain Management in Children during Local Anesthetic Administration by CCLAD: A Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2025Article
- Effect of cryoanesthesia and sweet tasting solution in reducing injection pain in pediatric patients aged 7-10 years: a randomized controlled trial.Journal of dental anesthesia and pain medicine · 2024Article
- From Diagnosis to Treatment: Exploring the Latest Management Trends in Cervical Intraepithelial Neoplasia.Cureus · 2023Review
- Advances in pediatric dentistry: new approaches to pain control and anxiety reduction in children - a narrative review.Journal of dental anesthesia and pain medicine · 2023Review
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProfound local anesthetic delivery promotes successful treatment for children in terms of easing their fear, anxiety, and discomfort during dental procedures. Local anesthetic injections are the utmost anticipated or anxious stimuli in the dental operatory. Precooling the oral mucosa by application of cryotherapy before local anesthetic injections can alter the pain perception in children. AIM AND
objectivesTo compare the efficacy of cryotherapy application and 20% benzocaine gel at reducing pain perception during buccal infiltration in pediatric patients. MATERIALS AND
methodsIn this split-mouth study, 30 pediatric patients between 7 years and 10 years of age who needed maxillary buccal infiltration of local anesthetics bilaterally for dental treatment were selected. They received cryotherapy (ice pack) on one quadrant (test group) for 2 minutes and 20% benzocaine topical gel on the contralateral quadrant (control group). A pediatric dentist blinded to the study assessed sound, eye, motor (SEM) scale based on patients' reaction during injection (objective method), and patients were instructed to use a visual analog scale (VAS) to rate their distress during injection (subjective method). Statistical analyses were performed using Wilcoxon and Mann-Whitney
resultsThe cryotherapy group had significantly reduced pain scores on the VAS scale (40.66 ± 14.60) when compared with the topical anesthetic gel group (61.33 ± 9.73). The cryotherapy group had reduced pain scores on the SEM scale as well (1.2 ± 0.1) when compared with the topical anesthetic gel group (1.6 ± 0.1), which was not statistically significant.
conclusionWhen compared with topical anesthetic gel, precooling the injection site with cryotherapy is beneficial in reducing pain before local anesthesia injection in pediatric patients. CLINICAL SIGNIFICANCE: Cryotherapy application eliminates the fear of pain ascribed to injection of local anesthesia and assists in providing pertinent dental care. HOW TO CITE THIS ARTICLE: Lakshmanan L, Ravindran V. Efficacy of Cryotherapy Application on the Pain Perception during Intraoral Injection: A Randomized Controlled Trial 2021;14(5):616-620.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.