ArticleScientific reports2021
Disclosing the bioactive metabolites involved in the in vitro anthelmintic effects of salt-tolerant plants through a combined approach using PVPP and HPLC-ESI-MS
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Solvent-Dependent Phenolic Profiling and Bioactivities ofMolecules (Basel, Switzerland) · 2026Article
- Phytochemical Study of the Anthelminthic Potential of Guadeloupean Plant Biodiversity.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Ovicidal activity and cytotoxicity of ethanolic extract of turmeric (Open veterinary journal · 2024Article
- Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review.Marine drugs · 2023Review
- Article
- Nutritional and Phyto-Therapeutic Value of the HalophytePlants (Basel, Switzerland) · 2022Article
- Article
- Impact of Seasonal and Organ-Related Fluctuations on the Anthelmintic Properties and Chemical Profile ofFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strategies to reduce dependence on synthetic drugs for the treatment of gastrointestinal nematodes (GIN) infections in ruminants include the search for novel anthelmintic scaffolds on plants, yet salt-tolerant plants remain overlooked. This study aims to evaluate the in vitro anthelmintic properties of selected salt-tolerant plants against GIN, and identify the potential bioactive secondary metabolites involved. For that purpose, 80% acetone/water extracts were prepared from dried biomass of aerial organs of nine salt-tolerant plant species and tested against Haemonchus contortus and Trichostrongylus colubriformis by the Larval Exsheathment Inhibition Assay (LEIA) and Egg Hatching Inhibition Assay (EHIA). Pistacia lentiscus, Limoniatrum monopetalum, Cladium mariscus and Helychrisum italicum picardi were the most active in both GIN and life stages. To investigate the role of polyphenols in the anthelmintic activity, four selected extracts were treated with polyvinylpolypyrrolidone (PVPP), and non-treated and treated samples were further characterized by high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MS
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