ArticleScientific reports2021
Evaluation of 2D super-resolution ultrasound imaging of the rat renal vasculature using ex vivo micro-computed tomography.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Fast 3-D Ultrasound Localization Microscopy via Projection-Based Processing Framework.IEEE transactions on medical imaging · 2026Article
- Human lymph node microvascular imaging using a fast contrast-free super-resolution ultrasound technique.Scientific reports · 2025Article
- Analysing the Renal Vasculature Using Super-Resolution Ultrasound Imaging: Considerations for Clinical and Research Applications.Diagnostics (Basel, Switzerland) · 2025Article
- Long-lasting microbubble-enhanced super-resolution ultrasound imaging unveils lymphatic activity in lymph node.Theranostics · 2025Article
- Large-scale super-resolution optoacoustic imaging facilitated by FeNP/ICG-loaded coreless polyelectrolyte microcapsules.Theranostics · 2025Article
- Article
- Advanced ultrasound methods to improve chronic kidney disease diagnosis.Npj imaging · 2024Review
- Three-dimensional super resolution ultrasound imaging with a multi-frequency hemispherical phased array.Medical physics · 2023Article
- Super-Resolution Ultrasound Imaging of Renal Vascular Alterations in Zucker Diabetic Fatty Rats during the Development of Diabetic Kidney Disease.Diagnostics (Basel, Switzerland) · 2023Article
- A hybrid approach to full-scale reconstruction of renal arterial network.Scientific reports · 2023Article
- Assessment of Transarterial Chemoembolization Using Super-resolution Ultrasound Imaging and a Rat Model of Hepatocellular Carcinoma.Ultrasound in medicine & biology · 2023Article
- Super-Resolution Ultrasound Imaging Provides Quantification of the Renal Cortical and Medullary Vasculature in Obese Zucker Rats: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- Super-Resolution Ultrasound Imaging Can Quantify Alterations in Microbubble Velocities in the Renal Vasculature of Rats.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors.
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Abstract
Super-resolution ultrasound imaging (SRUS) enables in vivo microvascular imaging of deeper-lying tissues and organs, such as the kidneys or liver. The technique allows new insights into microvascular anatomy and physiology and the development of disease-related microvascular abnormalities. However, the microvascular anatomy is intricate and challenging to depict with the currently available imaging techniques, and validation of the microvascular structures of deeper-lying organs obtained with SRUS remains difficult. Our study aimed to directly compare the vascular anatomy in two in vivo 2D SRUS images of a Sprague-Dawley rat kidney with ex vivo μCT of the same kidney. Co-registering the SRUS images to the μCT volume revealed visually very similar vascular features of vessels ranging from ~ 100 to 1300 μm in diameter and illustrated a high level of vessel branching complexity captured in the 2D SRUS images. Additionally, it was shown that it is difficult to use μCT data of a whole rat kidney specimen to validate the super-resolution capability of our ultrasound scans, i.e., validating the actual microvasculature of the rat kidney. Lastly, by comparing the two imaging modalities, fundamental challenges for 2D SRUS were demonstrated, including the complexity of projecting a 3D vessel network into 2D. These challenges should be considered when interpreting clinical or preclinical SRUS data in future studies.
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