Evidence map›Paper›PMID 34934073›Full record

Trial reportScientific reports2021

Permanent pacemaker dependency in patients with new left bundle branch block and new first degree atrioventricular block after transcatheter aortic valve implantation.

Bonnie Hartrampf, David Jochheim, Julius Steffen, Thomas Czermak, Sebastian Sadoni, Erik Lemmermöhle, Ina Klier, Heidi L Estner, Steffen Massberg, Julinda Mehilli and 2 more

Registry-linked trialAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06602609 (Remote Acute Monitoring-based Same-day Discharge Strategy of Post Transcatheter Aortic Valve Implantation Patients Versus Standard Care at 30-Day Follow-up), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06602609 narecruitingnot on this mapstarted 2024, after this paper: background citation

Remote Acute Monitoring-based Same-day Discharge Strategy of Post Transcatheter Aortic Valve Implantation Patients Versus Standard Care at 30-Day Follow-up

TypeinterventionalSponsorImperial College LondonRan2024 to 2028Enrolled216ConditionsAortic Valve Stenosis, Cardiac Conduction Disturbance, Digital Health, Transcatheter Aortic Valve ImplantationArmsRemote Patient Monitoring Strategy, Standard Medical Therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bonnie HartrampfDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany. Bonnie.Hartrampf@med.uni-muenchen.de.
David JochheimDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Julius SteffenDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Thomas CzermakDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Sebastian SadoniDepartment of Cardiac Surgery, University Hospital Munich, Ludwig Maximilians University, Munich, Germany.
Erik LemmermöhleDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Ina KlierDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Heidi L EstnerDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Steffen MassbergDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Julinda MehilliDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Korbinian Lackermair *Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.
Stephanie Fichtner *Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, E81377, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conduction disorders with need for permanent pacemaker (PPM) implantation remain frequent complications after transcatheter aortic valve implantation (TAVI). Up to 22% of PPM after TAVI are implanted for new onset left bundle branch block (LBBB) and atrioventricular block (AVB) I. However, clinical benefit and predictors of ventricular pacing in TAVI patients receiving PPM for this indication remain unclear. We retrospectively evaluated pacemaker interrogation data of patients who received a PPM post TAVI for new LBBB and new AVB I. The primary endpoint of this study was relevant ventricular pacing (ventricular pacing rate: Vp ≥ 1%) at the first outpatient pacemaker interrogation. Secondary endpoints were predictors for relevant ventricular pacing. At the first pacemaker interrogation (median follow up at 6.23 [2.8-14.8] months), median ventricular pacing frequency was 1.0% [0.1-17.8]. Out of 61 patients, 36 (59%) had Vp rates ≥ 1%. Patients with frequent ventricular pacing showed longer QRS duration (155 ms ± 17 ms vs. 144 ms ± 18 ms, p = 0.018) at the time of PPM implantation and were less likely treated with a balloon-expandable Edwards Sapiens Valve (39% vs. 12%, p = 0.040). Our findings suggest that the majority of patients with new LBBB and new AVB I after TAVI show relevant ventricular pacing rates at follow up. Further prospective studies are necessary to identify patients at higher risk of pacemaker dependency.

Indexed as

Pacemaker, ArtificialAgedAged, 80 and overAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialCausalityElectrophysiological PhenomenaFemaleHeart Valve ProsthesisHumansMaleRetrospective StudiesTranscatheter Aortic Valve ReplacementTreatment Outcome

Identifiers

PMID34934073
PMCPMC8692410

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.