Evidence map›Paper›PMID 34934049›Full record

ArticleSignal transduction and targeted therapy2021

Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry.

Shulong Zu, Dan Luo, Lili Li, Qing Ye, Rui-Ting Li, Yanan Wang, Meiling Gao, Heng Yang, Yong-Qiang Deng, Genhong Cheng

Open access · goldAbstract readLetterComment
In one paragraph

Article in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Article
  8. Preparing for the next viral threat with broad-spectrum antivirals.The Journal of clinical investigation · 2023
    Review
  9. Small molecules in the treatment of COVID-19.Signal transduction and targeted therapy · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shulong Zu *Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dan Luo *State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Lili Li *Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qing Ye *State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Rui-Ting LiState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Yanan WangSuzhou Func Biotech Inc, Suzhou, Jiangsu, China.
Meiling GaoInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Heng YangInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. yhmyt@hotmail.com.ORCID http://orcid.org/0000-0002-1491-4490
Yong-Qiang DengState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China. dengyq1977@126.com.ORCID http://orcid.org/0000-0002-2306-1039
Genhong ChengDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA. gcheng@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-6713-2783
Academy of Military Medical Sciences · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of California, Los Angeles · US

Funding

Viral Mediated Type I Interferon InductionR01AI069120 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG · 2006 to 2021
$6.0M
Genetic evolution, pathogenesis and immune responses in mother to child transmission of ZIKVR01AI140718 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG, JUNG, JAE U · 2018 to 2022
$3.8M
Develop broad-spectrum antiviral agents against COVID-19 based on innate immune response to SARS-CoV-2 infectionR01AI158154 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JUNG, MICHAEL E · 2020 to 2025
$1.9M
NIAID NIH HHS R01 AI069120NIAID NIH HHS R01 AI140718NIAID NIH HHS R01 AI158154
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Virus InternalizationClomipheneHumansSARS-CoV-2TamoxifenClomipheneTamoxifen

Identifiers

PMID34934049
PMCPMC8688909
OpenAlexW4200329392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.