ArticleJournal of neurology, neurosurgery, and psychiatry2022
Frailty, lifestyle, genetics and dementia risk.
Article in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06741865 (Intervention Strategies for Preserving Intellectual Resilience and Engagement), which is not on this map. Cited by 90 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intervention Strategies for Preserving Intellectual Resilience and Engagement
Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature.Journal of the American Geriatrics Society · 2026Pooled it
- Increased risk of dementia among people with a history of fractures: a systematic review and meta-analysis of population-based studies.Frontiers in neurology · 2023Pooled it
- Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies.Frontiers in aging neuroscience · 2022Pooled it
- Association Between the Frailty and Cognitive Impairment Among Patients With Hypertension-A Post Hoc Analysis of the SPRINT Trial.Journal of the American Heart Association · 2023Trial
- Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial.GeroScience · 2023Trial
- Frailty and risk of common chronic diseases among cancer survivors: a prospective cohort study.Journal of cancer survivorship : research and practice · 2026Article
- Integrating frailty into decision-making for disease-modifying therapies in Alzheimer's disease: a proposed expert-opinion based approach.The journal of prevention of Alzheimer's disease · 2026Review
- Frailty assessment in naturally aged mouse models: classification, limitations, and future directions.GeroScience · 2026Review
- Comparative Analysis by Machine Learning of Geriatric Frailty and Alzheimer's Disease Classification Using Independent Datasets.Life (Basel, Switzerland) · 2026Article
- Randomized Controlled Trial of Individualized Intervention for Frailty Reversal in Older Patients With Nondialysis CKD.Kidney international reports · 2026Article
- Association of frailty and metabolism with multi-state model in fatty liver disease, diabetes mellitus and all-cause mortality.Diabetology & metabolic syndrome · 2026Article
- Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study.The Journal of frailty & aging · 2026Article
- Association of Frailty and Frailty Trajectory with Risk for Respiratory Infectious Diseases.Emerging infectious diseases · 2026Article
- Dissecting genetic variant contributions to neurodegenerative disorders through targeted gene sequencing in a Sicilian population.Scientific reports · 2026Article
- Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.Journal of advanced research · 2026Article
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of frailty with dementia and the impact of frailty on antihypertensive treatment protection against dementia in older hypertensive adults.Age and ageing · 2026Article
- Prospective association between the triglyceride-glucose index and frailty in middle-aged and older adults: insights from a nationwide cohort study.European journal of medical research · 2026Article
- Network analysis as a tool to illustrate the population-level complex prescribing to community-dwelling people living with dementia.International journal of population data science · 2026Article
- Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty.Frontiers in cell and developmental biology · 2026Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics.
methodsWe explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data.
resultsThe analytical sample had a mean age of 64.1 years at baseline (SD=2.9) and 53% were women. Incident dementia was detected in 1762 participants (median follow-up time=8.0 years). High frailty was associated with increased dementia risk independently of genetic risk (HR 3.68, 95% CI 3.11 to 4.35). Frailty mediated 44% of the relationship between healthy lifestyle behaviours and dementia risk (indirect effect HR 0.95, 95% CI 0.95 to 0.96). Participants at high genetic risk and with high frailty had 5.8 times greater risk of incident dementia compared with those at low genetic risk and with low frailty (HR 5.81, 95% CI 4.01 to 8.42). Higher genetic risk was most influential in those with low frailty (HR 1.31, 95% CI 1.22 to 1.40) but not influential in those with high frailty (HR 1.09, 95% CI 0.92 to 1.28).
conclusionFrailty is strongly associated with dementia risk and affects the risk attributable to genetic factors. Frailty should be considered an important modifiable risk factor for dementia and a target for dementia prevention strategies, even among people at high genetic risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.