ArticleBMJ open2021
Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A Protocol to Acquire Infant Heart Rate Variability in the Rohingya Camps and Surrounding Communities in Cox's Bazar, Bangladesh.Psychophysiology · 2026Article
- Maturational physiology in preterm infants: morbidity impact and 2-year neurodevelopmental outcome.Pediatric research · 2026Article
- Reduced heart rate variability predicts severe intraventricular haemorrhage in extremely preterm infants.Pediatric research · 2026Article
- Heart Rate Variability in Newborns From Diabetic Mothers: Clinical Application and Significance.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Review
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- Development and multicenter validation of an explainable machine learning diagnostic criteria for pediatric abdominal sepsis.NPJ digital medicine · 2026Article
- Establishing normative values for short-term heart rate variability indices in healthy infants in the emergency department.Annals of translational medicine · 2025Article
- Exploring Computational Techniques in Preprocessing Neonatal Physiological Signals for Detecting Adverse Outcomes: Scoping Review.Interactive journal of medical research · 2024Article
- Full-Term and Preterm Newborns Differ More Significantly in Photoplethysmographic Waveform Variability than Heart Rate Variability.Life (Basel, Switzerland) · 2024Article
- Prediction of outcome of hypoxic-ischemic encephalopathy in newborns undergoing therapeutic hypothermia using heart rate variability.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- The Effect of Caffeine on Heart Rate Variability in Newborns: A Pilot Study.Life (Basel, Switzerland) · 2023Article
- Methods for analyzing infant heart rate variability: A preliminary study.Birth defects research · 2023Article
- Towards precision medicine for extubation of extremely preterm infants: is variability the spice of life?Pediatric research · 2023Article
- Comparing Full and Pre-Term Neonates' Heart Rate Variability in Rest Condition and during Spontaneous Interactions with Their Parents at Home.Healthcare (Basel, Switzerland) · 2023Article
- Donkey Heart Rate and Heart Rate Variability: A Scoping Review.Animals : an open access journal from MDPI · 2023Article
- Heart rate variability analysis for the prediction of EEG grade in infants with hypoxic ischaemic encephalopathy within the first 12 h of birth.Frontiers in pediatrics · 2022Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal heart rate variability (HRV) is widely used as a research tool. However, HRV calculation methods are highly variable making it difficult for comparisons between studies.
objectivesTo describe the different types of investigations where neonatal HRV was used, study characteristics, and types of analyses performed. ELIGIBILITY CRITERIA: Human neonates ≤1 month of corrected age. SOURCES OF EVIDENCE: A protocol and search strategy of the literature was developed in collaboration with the McGill University Health Center's librarians and articles were obtained from searches in the Biosis, Cochrane, Embase, Medline and Web of Science databases published between 1 January 2000 and 1 July 2020. CHARTING
methodsA single reviewer screened for eligibility and data were extracted from the included articles. Information collected included the study characteristics and population, type of HRV analysis used (time domain, frequency domain, non-linear, heart rate characteristics (HRC) parameters) and clinical applications (physiological and pathological conditions, responses to various stimuli and outcome prediction).
resultsOf the 286 articles included, 171 (60%) were small single centre studies (sample size <50) performed on term infants (n=136). There were 138 different types of investigations reported: physiological investigations (n=162), responses to various stimuli (n=136), pathological conditions (n=109) and outcome predictor (n=30). Frequency domain analyses were used in 210 articles (73%), followed by time domain (n=139), non-linear methods (n=74) or HRC analyses (n=25). Additionally, over 60 different measures of HRV were reported; in the frequency domain analyses alone there were 29 different ranges used for the low frequency band and 46 for the high frequency band.
conclusionsNeonatal HRV has been used in diverse types of investigations with significant lack of consistency in analysis methods applied. Specific guidelines for HRV analyses in neonates are needed to allow for comparisons between studies.
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