Evidence map›Paper›PMID 34933635›Full record

ArticleNeurorehabilitation and neural repair2022

Genetic Factors, Brain Atrophy, and Response to Rehabilitation Therapy After Stroke.

Steven C Cramer, Jill See, Brent Liu, Matthew Edwardson, Ximing Wang, Shlomit Radom-Aizik, Fadia Haddad, Babak Shahbaba, Steven L Wolf, Alexander W Dromerick and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Steven C CramerNeurology, 12222University of California, Irvine, CA, USA.ORCID 0000-0002-6214-6211
Jill SeeNeurology, 12222University of California, Irvine, CA, USA.
Brent Liu5116Image Processing and Informatics Lab, Dept. Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Matthew EdwardsonNeurology, 8368Georgetown University, Washington, DC, USA.ORCID 0000-0002-0327-5531
Ximing Wang5116Image Processing and Informatics Lab, Dept. Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Shlomit Radom-Aizik8788Pediatrics, University of California, Irvine, CA, USA.
Fadia Haddad8788Pediatrics, University of California, Irvine, CA, USA.
Babak Shahbaba8788Statistics, University of California, Irvine, CA, USA.ORCID 0000-0002-8102-1609
Steven L Wolf1371Dept. Rehabilitation Medicine, Division of Physical Therapy Education, Emory University; Atlanta VA Health Care System, Center for Visual and Neurocognitive Rehabilitation.ORCID 0000-0002-9446-8995
Alexander W DromerickNeurology, 8368Georgetown University, Washington, DC, USA.
Carolee J Winstein5116Div. Biokinesiology and Physical Therapy and Dept. Neurology, University of Southern California, Los Angeles, CA, USA.
University of California, Irvine · USUniversity of Southern California · USGeorgetown University · USEmory University · USUniversity of California, Los Angeles · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Interdisciplinary Comprehensive Arm Rehab Evaluation (I-CARE) Stroke InitiativeU01NS056256 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DROMERICK, ALEXANDER W, WINSTEIN, CAROLEE J · 2008 to 2013
$12.7M
Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
BDNF Genotype, Cortical Plasticity and Recovery From StrokeR01NS058755 · NINDS · UNIVERSITY OF FLORIDA · PI KLEIM, JEFFREY A · 2008 to 2011
$1.5M
Brain plasticity and rehabilitation after strokeK24HD074722 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C. · 2013 to 2017
$588k
NCATS NIH HHS UL1 TR001414NICHD NIH HHS K12 HD093427NICHD NIH HHS K24 HD074722NINDS NIH HHS R01 NS058755NINDS NIH HHS U01 NS056256
6 · The paper itself

Abstract

objectivePatients show substantial differences in response to rehabilitation therapy after stroke. We hypothesized that specific genetic profiles might explain some of this variance and, secondarily, that genetic factors are related to cerebral atrophy post-stroke.

methodsThe phase 3 ICARE study examined response to motor rehabilitation therapies. In 216 ICARE enrollees, DNA was analyzed for presence of the BDNF val

resultsSubjects were 61±13 years old (mean±SD) and enrolled 43±22 days post-stroke; 19.7% were BDNF val

conclusionNeither the val

Indexed as

EndophenotypesOutcome Assessment, Health CareStrokeStroke RehabilitationAgedApolipoprotein E4AtrophyBiomarkersBrain-Derived Neurotrophic FactorFemaleHumansMaleMiddle AgedNeuroimagingApolipoprotein E4BiomarkersBrain-Derived Neurotrophic Factorbiomarkerendophenotypegeneticsimagingrehabilitationstroke

Identifiers

PMID34933635
PMCPMC8792305
OpenAlexW4200060780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.