Evidence map›Paper›PMID 34933614›Full record

SynthesisAnnals of medicine2021

Gut permeability and osteoarthritis, towards a mechanistic understanding of the pathogenesis: a systematic review.

Giorgio Guido, Guido Ausenda, Veronica Iascone, Emanuele Chisari

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  4. mSystems · 2025
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  9. Heat-TreatedCells · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Giorgio GuidoDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Guido AusendaFaculty of Medicine, University of Milan, Milan, Italy.
Veronica IasconeExperimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Emanuele ChisariRothman Orthopaedic Institute at Thomas Jefferson University, Washington Township, NJ, USA.ORCID 0000-0003-0933-6806
GNA University · INThomas Jefferson University · USUniversity of Catania · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common condition affecting human joints. Along with mechanical and genetic factors, low-grade inflammation is increasingly supported as a causal factor in the development of OA. Gut microbiota and intestinal permeability,

Indexed as

Gastrointestinal MicrobiomeOsteoarthritisDysbiosisHumansInflammationPermeabilitygut microbiotaintestinal permeabilityjoint inflammationmicrobiomeOsteoarthritistight junctions

Identifiers

PMID34933614
PMCPMC8725942
OpenAlexW4200107345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.