Evidence map›Paper›PMID 34933456›Full record

ArticlemBio2021

Horizontal-Acquisition of a Promiscuous Peptidoglycan-Recycling Enzyme Enables Aphids To Influence Symbiont Cell Wall Metabolism.

Thomas E Smith, Mijoon Lee, Maria D Person, Dusan Hesek, Shahriar Mobashery, Nancy A Moran

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. A Horizontally Transferred Plant Fatty Acid Desaturase Gene Steers Whitefly Reproduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thomas E SmithDepartment of Integrative Biology, University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-4031-7753
Mijoon LeeDepartment of Chemistry and Biochemistry, University of Notre Damegrid.131063.6, Notre Dame, Indiana, USA.
Maria D PersonCenter for Biomedical Research Support Proteomics Facility, University of Texas at Austin, Austin, Texas, USA.
Dusan HesekDepartment of Chemistry and Biochemistry, University of Notre Damegrid.131063.6, Notre Dame, Indiana, USA.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Damegrid.131063.6, Notre Dame, Indiana, USA.
Nancy A MoranDepartment of Integrative Biology, University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0003-2983-9769
The University of Texas at Austin · USUniversity of Notre Dame · US

Funding

Elucidating the molecular bases of species interactions in host-associated bacterial communitiesR35GM131738 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MORAN, NANCY A. · 2019 to 2023
$2.0M
Cell-Wall Recycling and Nexus to Antibiotic ResistanceR35GM131685 · NIGMS · UNIVERSITY OF NOTRE DAME · PI MOBASHERY, SHAHRIAR · 2019 to 2023
$1.9M
Investigations of the role of host controlled peptidoglycan recycling in the regulation of the pea aphid-Buchnera symbiosisF32GM126706 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI SMITH, THOMAS E · 2017 to 2020
$197k
NIGMS NIH HHS F32 GM126706NIGMS NIH HHS R35 GM131685NIGMS NIH HHS R35 GM131738
6 · The paper itself

Abstract

During evolution, enzymes can undergo shifts in preferred substrates or in catalytic activities. An intriguing question is how enzyme function changes following horizontal gene transfer, especially for bacterial genes that have moved to animal genomes. Some insects have acquired genes that encode enzymes for the biosynthesis of bacterial cell wall components and that appear to function to support or control their obligate endosymbiotic bacteria. In aphids, the bacterial endosymbiont Buchnera aphidicola provides essential amino acids for aphid hosts but lacks most genes for remodeling of the bacterial cell wall. The aphid genome has acquired seven genes with putative functions in cell wall metabolism that are primarily expressed in the aphid cells harboring

Indexed as

Gene Transfer, HorizontalAnimalsAphidsBacterial ProteinsBuchneraCell WallInsect ProteinsN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanSymbiosisBacterial ProteinsInsect ProteinsN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanBuchneracarboxypeptidasecell wallendopeptidaseenzyme promiscuityhorizontal gene transfermultifunctionalpea aphidpeptidoglycansymbiosis

Identifiers

PMID34933456
PMCPMC8689515
OpenAlexW4200113320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.