Evidence map›Paper›PMID 34933448›Full record

ArticlemBio2021

High-Throughput CRISPR Screens To Dissect Macrophage-

Yong Lai, Liang Cui, Gregory H Babunovic, Sarah M Fortune, John G Doench, Timothy K Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Yong LaiAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore.
Liang CuiAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore.
Gregory H BabunovicDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
John G DoenchBroad Institute, Cambridge, Massachusetts, USA.
Timothy K LuAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore.ORCID 0000-0002-3918-8923
Broad Institute · USHarvard University · USCambridge Electronics (United States) · USSingapore-MIT Alliance for Research and Technology · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shigellosis causes most diarrheal deaths worldwide, particularly affecting children.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCytokinesDysentery, BacillaryHigh-Throughput Nucleotide SequencingHumansMacrophagesMonocytesShigella flexneriToll-Like Receptor 2CytokinesTLR2 protein, humanToll-Like Receptor 2CRISPR-Cas9 knockout screenCRISPRi screengenome-wide CRISPR screenshost-directed therapyhost-pathogen interactionsmacrophagespyruvate catabolismshigellosisTLR1/2 signaling

Identifiers

PMID34933448
PMCPMC8689513
OpenAlexW4226024989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.