Evidence map›Paper›PMID 34933415›Full record

ReviewInternational forum of allergy & rhinology2022

The management of cystic fibrosis chronic rhinosinusitis: An evidenced-based review with recommendations.

Daniel B Spielman, Daniel M Beswick, Adam J Kimple, Brent A Senior, Kasper Aanaes, Bradford A Woodworth, Rodney J Schlosser, Stella Lee, Do-Yeon Cho, Nithin D Adappa and 2 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International forum of allergy & rhinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  4. Article
  5. Article
  6. Observational
  7. Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Daniel B SpielmanDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0003-2602-0416
Daniel M BeswickDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.ORCID 0000-0001-8612-5442
Adam J KimpleDepartment of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC.
Brent A SeniorDepartment of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC.
Kasper AanaesDepartment of Otorhinolaryngology, Head and Neck Surgery & Audiology, University of Copenhagen, Copenhagen, Denmark.
Bradford A WoodworthDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-3292-9167
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Stella LeeDivision of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Boston, MA.
Do-Yeon ChoDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-5173-8959
Nithin D AdappaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA.
Emily DiMangoDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, New York, NY.
David A GudisDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-1938-9349
Columbia University Irving Medical Center · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USHospital of the University of Pennsylvania · USMedical University of South Carolina · USUniversity of California, Los Angeles · USUniversity of Copenhagen · DK

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Steven Mark Rowe · 2007 to 2026
$23.0M
Dysbiosis of the Sinus Microbiota in Chronic RhinosinusitisK08AI146220 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2019 to 2021
$467k
Impact of mucin fermenting microbes on the virulence of Pseudomonas aeruginosa in chronic rhinosinusitisR21AI168894 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2022 to 2023
$408k
NIAID NIH HHS K08 AI146220NIAID NIH HHS R21 AI168894NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

backgroundCystic fibrosis (CF) chronic rhinosinusitis (CRS) has emerged as a distinct diagnostic entity, unique from other endotypes of CRS in its presentation, pathophysiology, diagnosis, treatment, and outcomes. As the sinonasal health of this patient population may have broad effects on pulmonary health and quality of life, a comprehensive understanding of the diagnostic and therapeutic approach to CF CRS is essential. In recognizing recent scientific advances and unique treatment modalities specific to this challenging patient population, in this review we systematically evaluate the scientific literature and provide an evidenced-based review with recommendations (EBRR) for fundamental management principles of CF CRS.

methodsA systematic review of the literature was performed. Studies evaluating interventions for the management of CF CRS were included. An iterative review process was implemented in accordance with EBRR guidelines. A treatment recommendation was generated based on an assessment of the benefits, harms, and the overall grade of evidence.

resultsWe evaluated the published literature on 5 unique topics. Each of the following therapeutic categories was investigated explicitly for treatment outcomes in patients with CF CRS: (1) nasal saline; (2) intranasal corticosteroids (INCS); (3) topical antibiotics; (4) cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy; and (5) endoscopic sinus surgery (ESS).

conclusionBased on the currently available evidence, nasal saline, ESS, and CFTR modulators are recommended in the management of CF CRS when appropriate. INCS and topical antibiotics are options. Clinical judgment and experience are essential in caring for patients with this uniquely challenging disorder.

Indexed as

Cystic FibrosisRhinitisSinusitisAnti-Bacterial AgentsChronic DiseaseCystic Fibrosis Transmembrane Conductance RegulatorHumansQuality of LifeAnti-Bacterial AgentsCystic Fibrosis Transmembrane Conductance Regulatorchronic rhinosinusitiscystic fibrosisendoscopic sinus surgeryirrigationsmedical therapy of chronic rhinosinusitispediatric rhinologytopical therapy for chronic rhinosinusitis

Identifiers

PMID34933415
PMCPMC10083096
OpenAlexW4200018324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.