ReviewCurrent opinion in microbiology2022
Genetic mechanisms governing sporulation initiation in Clostridioides difficile.
Review in Current opinion in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026Article
- Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026Review
- Deciphering strain differences in codY regulation ofMicrobiology spectrum · 2026Article
- Epithelial model-dependent host-microbe interactions in human intestinal models under anaerobic Transwell co-culture.Frontiers in microbiology · 2026Article
- The Pxp Complex Detoxifies 5-Oxoproline and Promotes the Growth of Clostridioides difficile.Molecular microbiology · 2025Article
- A metabolite dehydrogenase pathway represses sporulation of Clostridioides difficile.Anaerobe · 2025Article
- Review
- Uncovering newMicrobiology spectrum · 2024Article
- The small acid-soluble proteins of Clostridioides difficile regulate sporulation in a SpoIVB2-dependent manner.PLoS pathogens · 2024Article
- The small acid-soluble proteins ofbioRxiv : the preprint server for biology · 2024Article
- A conserved switch controls virulence, sporulation, and motility in C. difficile.PLoS pathogens · 2024Article
- Review
- The pH-responsive SmrR-SmrT system modulatesInfection and immunity · 2024Article
- Fight or flee, a vital choice formLife · 2024Article
- Clostridioides difficile Sporulation.Advances in experimental medicine and biology · 2024Review
- A unique sigma/anti-sigma system in the actinomycete Actinoplanes missouriensis.Nature communications · 2023Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Expanding our grasp of two-component signaling inJournal of bacteriology · 2023Article
- Glycine fermentation byInfection and immunity · 2023Article
- Review of the Impact of Biofilm Formation on RecurrentMicroorganisms · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host's gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, permitting long-term survival against environmental insults and efficient transmission from host to host. Although the morphological stages of spore formation are similar between C. difficile and other well-studied endospore-forming bacteria, the C. difficile genome does not appear to encode many of the known, conserved regulatory factors that are necessary to initiate sporulation in other spore-forming bacteria. The absence of early sporulation-specific orthologs suggests that C. difficile has evolved to control sporulation initiation in response to its unique and specific ecological niche and environmental cues within the host. Here, we review our current understanding and highlight the recent discoveries that have begun to unravel the regulatory pathways and molecular mechanisms by which C. difficile induces spore formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.