Evidence map›Paper›PMID 34932961›Full record

ArticleCurrent biology : CB2021

Transforming a neural circuit to function without oxygen and glucose delivery.

Nikolaus Bueschke, Lara do Amaral-Silva, Sasha Adams, Joseph M Santin

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Brain-derived ketone bodies can replace glucose to power neural function.bioRxiv : the preprint server for biology · 2026
    Article
  3. Frogs uncouple neural activity from oxygen consumption after hibernation.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Neural Processing without OPhysiology (Bethesda, Md.) · 2024
    Review
  8. Article
  9. Article
  10. Plasticity in the Functional Properties of NMDA Receptors Improves Network Stability during Severe Energy Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Synapses: The Brain's Energy-Demanding Sites.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nikolaus BueschkeDepartment of Biology, University of North Carolina at Greensboro, 377 Sullivan Building, Greensboro, NC 27412, USA.
Lara do Amaral-SilvaDepartment of Biology, University of North Carolina at Greensboro, 377 Sullivan Building, Greensboro, NC 27412, USA.
Sasha AdamsDepartment of Biology, University of North Carolina at Greensboro, 377 Sullivan Building, Greensboro, NC 27412, USA.
Joseph M SantinDepartment of Biology, University of North Carolina at Greensboro, 377 Sullivan Building, Greensboro, NC 27412, USA. Electronic address: jmsantin@uncg.edu.
University of North Carolina at Greensboro · US

Funding

Acquiring resistance to anoxia in neural circuit functionR15NS112920 · NINDS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI OSENA, AYALEW LIGABA · 2020 to 2020
$355k
NINDS NIH HHS R15 NS112920
6 · The paper itself

Abstract

Disruptions in the delivery of oxygen and glucose impair the function of neural circuits, with lethal consequences commonly observed in stroke and cardiac arrest. Intense focus has been placed on understanding how to overcome neuronal failure during energy stress. Important insights into neuroprotective strategies have come from studies of evolutionary adaptations for survival in hypoxic environments, such as those seen in turtles, naked mole-rats, and several other animals

Indexed as

HibernationOxygenAnimalsGlucoseHypoxiaMole RatsGlucoseOxygen

Identifiers

PMID34932961
PMCPMC8711626
OpenAlexW4200204371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.