ArticleNeuron2022
Cognitive strategies shift information from single neurons to populations in prefrontal cortex.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Compression as a neural mechanism of mnemonic chunking in prefrontal cortex.Current biology : CB · 2026Article
- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Unraveling the roles of spatial working memory sustained and selective neurons in prefrontal cortex.Communications biology · 2025Article
- Recurrent activity propagates through labile ensembles in macaque dorsolateral prefrontal microcircuits.Current biology : CB · 2025Article
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Timescales of learning in prefrontal cortex.Nature reviews. Neuroscience · 2024Review
- Article
- Sequential neuronal processing of number values, abstract decision, and action in the primate prefrontal cortex.PLoS biology · 2024Article
- The neuronal implementation of representational geometry in primate prefrontal cortex.Science advances · 2023Article
- Value dynamics affect choice preparation during decision-making.Nature neuroscience · 2023Article
- Muscimol-induced inactivation of the ventral prefrontal cortex impairs counting performance in rhesus monkeys.Science progressArticle
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3 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons in primate lateral prefrontal cortex (LPFC) play a critical role in working memory (WM) and cognitive strategies. Consistent with adaptive coding models, responses of these neurons are not fixed but flexibly adjust on the basis of cognitive demands. However, little is known about how these adjustments affect population codes. Here, we investigated ensemble coding in LPFC while monkeys implemented different strategies in a WM task. Although single neurons were less tuned when monkeys used more stereotyped strategies, task information could still be accurately decoded from neural populations. This was due to changes in population codes that distributed information among a greater number of neurons, each contributing less to the overall population. Moreover, this shift occurred for task-relevant, but not irrelevant, information. These results demonstrate that cognitive strategies that impose structure on information held in mind rearrange population codes in LPFC, such that information becomes more distributed among neurons in an ensemble.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.