Evidence map›Paper›PMID 34932563›Full record

Trial reportPloS one2021

Estimation of lifetime survival and predictors of mortality among TB with HIV co-infected children after test and treat strategies launched in Northwest, Ethiopia, 2021; a multicentre historical follow-up study.

Ermias Sisay Chanie, Getnet Asmare Gelaye, Tesfaye Yimer Tadesse, Dejen Getaneh Feleke, Wubet Taklual Admas, Eshetie Molla Alemu, Melkalem Mamoye Azanaw, Sofonyas Abebaw Tiruneh, Alemayehu Digssie Gebremariam, Binyam Minuye Birhane and 2 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 9 pooled it
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 9 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ermias Sisay ChanieDepartment of Pediatric and Child health Nursing, College of Health Sciences, Debre Tabor University, Ethiopia.ORCID 0000-0002-3124-5380
Getnet Asmare GelayeDepartment of Pediatric and Child health Nursing, College of Health Sciences, Debre Tabor University, Ethiopia.
Tesfaye Yimer TadesseDepartment of Pharmacology, College of Health Sciences, Debre Tabor University, Ethiopia.
Dejen Getaneh FelekeDepartment of Pediatric and Child health Nursing, College of Health Sciences, Debre Tabor University, Ethiopia.
Wubet Taklual AdmasDepartment of Public health, College of Health Sciences, Debre Tabor University, Ethiopia.
Eshetie Molla AlemuDepartment of Public health, College of Health Sciences, Debre Tabor University, Ethiopia.
Melkalem Mamoye AzanawDepartment of Public health, College of Health Sciences, Debre Tabor University, Ethiopia.ORCID 0000-0002-2897-8903
Sofonyas Abebaw TirunehDepartment of Public health, College of Health Sciences, Debre Tabor University, Ethiopia.
Alemayehu Digssie GebremariamDepartment of Public health, College of Health Sciences, Debre Tabor University, Ethiopia.
Binyam Minuye BirhaneDepartment of Maternity and Neonatal health Nursing, College of Health Sciences, Debre Tabor University, Ethiopia.
Wubet Alebachew BayihDepartment of Maternity and Neonatal health Nursing, College of Health Sciences, Debre Tabor University, Ethiopia.ORCID 0000-0003-1439-4402
Getachew AragieDepartment of Pediatric and Child health Nursing, College of Health Sciences, Debre Tabor University, Ethiopia.
Debre Tabor University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn resource-limited settings, the mortality rate among tuberculosis and human Immunodeficiency virus co-infected children is higher. However, there is no adequate evidence in Ethiopia in general and in the study area in particular. Hence, this study aims to estimate lifetime survival and predictors of mortality among TB with HIV co-infected children after test and treat strategies launched in Northwest Ethiopia Hospitals, 2021.

methodsInstitution-based historical follow-up study was conducted in Northwest Ethiopia Hospitals among 227 Tuberculosis and Human Immunodeficiency Virus co-infected children from March 1, 2014, to January 12, 2021. The data were entered into Epi info-7 and then exported to STATA version 14 for analysis. The log-rank test was used to estimate the curve difference of the predictor variables. Bivariable cox-proportional hazard models were employed for each predictor variable. Additionally, those variables having a p-value < 0.25 in bivariate analysis were fitted into a multivariable cox-proportional hazards model. P-value < 0.05 was used to declare significance associated with the dependent variable.

resultsFrom a total of 227 TB and HIV co-infected children, 39 died during the follow-up period. The overall mortality rate was 3.7 (95% CI (confidence interval): 2.9-4.7) per 100 person-years with a total of 1063.2-year observations. Cotrimoxazole preventive therapy (CPT) non-users [Adjusted Hazarded Ratio (AHR) = 3.8 (95% CI: 1.64-8.86)], presence of treatment failure [AHR = 3.0 (95% CI: 1.14-78.17)], and Cluster of differentiation 4(CD4) count below threshold [AHR = 2.7 (95% CI: 1.21-6.45)] were significant predictors of mortality.

conclusionIn this study, the mortality rate among TB and HIV co-infected children was found to be very high. The risk of mortality among TB and HIV co-infected children was associated with treatment failure, CD4 count below the threshold, and cotrimoxazole preventive therapy non-users. Further research should conduct to assess and improve the quality of ART service in Northwest Ethiopia Hospitals.

Indexed as

CoinfectionHIV-1HIV InfectionsMycobacterium tuberculosisTuberculosisCD4 Lymphocyte CountChildChild, PreschoolEthiopiaFemaleFollow-Up StudiesHumansInfantMaleTrimethoprim, Sulfamethoxazole Drug CombinationTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID34932563
PMCPMC8691625
OpenAlexW4200173247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.