Evidence map›Paper›PMID 34932493›Full record

ArticleJournal of medical Internet research2022

SMART COVID Navigator, a Clinical Decision Support Tool for COVID-19 Treatment: Design and Development Study.

Varun Suraj, Catherine Del Vecchio Fitz, Laura B Kleiman, Suresh K Bhavnani, Chinmay Jani, Surbhi Shah, Rana R McKay, Jeremy Warner, Gil Alterovitz

Open access · goldAbstract read
In one paragraph

Article in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Varun SurajBiomedical Cybernetics Laboratory, Brigham and Women's Hospital, Boston, MA, United States.ORCID 0000-0002-9090-0859
Catherine Del Vecchio FitzReboot Rx, Boston, MA, United States.ORCID 0000-0002-9554-411X
Laura B KleimanReboot Rx, Boston, MA, United States.ORCID 0000-0003-1855-4725
Suresh K BhavnaniPreventive Medicine and Population Health Institute for Translational Sciences, University of Texas Medical Branch, University of Texas Health Science Center in Houston, Houston, TX, United States.ORCID 0000-0002-9282-8838
Chinmay JaniDepartment of Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, United States.ORCID 0000-0002-6917-5568
Surbhi ShahHematology, Oncology and Bone Marrow Transplantation, Mayo Clinic, Phoenix, AZ, United States.ORCID 0000-0003-0978-5687
Rana R McKayDepartment of Medicine and Urology, University of California, San Diego, CA, United States.ORCID 0000-0002-0581-7963
Jeremy Warner *Medicine and Biomedical Informatics, Vanderbilt University, Nashville, TN, United States.ORCID 0000-0002-2851-7242
Gil Alterovitz *Biomedical Cybernetics Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-0495-7059
Brigham and Women's Hospital · USMount Auburn Hospital · USUniversity of California San Diego · USVanderbilt University · USWinnMed · US

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
Network Analysis for a Data-Driven Approach to Cancer CareU01CA231840 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARNER, JEREMY LYLE · 2018 to 2020
$1.2M
NCATS NIH HHS UL1 TR001439NCI NIH HHS U01 CA231840NIA NIH HHS P30 AG024832
6 · The paper itself

Abstract

backgroundCOVID-19 caused by SARS-CoV-2 has infected 219 million individuals at the time of writing of this paper. A large volume of research findings from observational studies about disease interactions with COVID-19 is being produced almost daily, making it difficult for physicians to keep track of the latest information on COVID-19's effect on patients with certain pre-existing conditions.

objectiveIn this paper, we describe the creation of a clinical decision support tool, the SMART COVID Navigator, a web application to assist clinicians in treating patients with COVID-19. Our application allows clinicians to access a patient's electronic health records and identify disease interactions from a large set of observational research studies that affect the severity and fatality due to COVID-19.

methodsThe SMART COVID Navigator takes a 2-pronged approach to clinical decision support. The first part is a connection to electronic health record servers, allowing the application to access a patient's medical conditions. The second is accessing data sets with information from various observational studies to determine the latest research findings about COVID-19 outcomes for patients with certain medical conditions. By connecting these 2 data sources, users can see how a patient's medical history will affect their COVID-19 outcomes.

resultsThe SMART COVID Navigator aggregates patient health information from multiple Fast Healthcare Interoperability Resources-enabled electronic health record systems. This allows physicians to see a comprehensive view of patient health records. The application accesses 2 data sets of over 1100 research studies to provide information on the fatality and severity of COVID-19 for several pre-existing conditions. We also analyzed the results of the collected studies to determine which medical conditions result in an increased chance of severity and fatality of COVID-19 progression. We found that certain conditions result in a higher likelihood of severity and fatality probabilities. We also analyze various cancer tissues and find that the probabilities for fatality vary greatly depending on the tissue being examined.

conclusionsThe SMART COVID Navigator allows physicians to predict the fatality and severity of COVID-19 progression given a particular patient's medical conditions. This can allow physicians to determine how aggressively to treat patients infected with COVID-19 and to prioritize different patients for treatment considering their prior medical conditions.

Indexed as

COVID-19Decision Support Systems, ClinicalElectronic Health RecordsHumansSARS-CoV-2Softwareclinical decision supportCOVID-19FHIRprecision medicineweb application

Identifiers

PMID34932493
PMCPMC8862760
OpenAlexW3203366537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.