Evidence map›Paper›PMID 34932373›Full record

ArticleScience signaling2021

Induction of

Sara H Small, E Jessica Tang, Ryan L Ragland, Yaroslava Ruzankina, David W Schoppy, Rahul S Mandal, M Rebecca Glineburg, Zgjim Ustelenca, Daniel J Powell, Fiona Simpkins and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sara H SmallDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1246-0250
E Jessica TangDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ryan L RaglandDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yaroslava RuzankinaDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
David W SchoppyDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rahul S MandalDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8939-3362
M Rebecca GlineburgDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8615-2894
Zgjim UstelencaDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel J PowellDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-5966-8908
Fiona SimpkinsPenn Ovarian Cancer Research Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0840-2368
F Bradley JohnsonDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7443-7227
Eric J BrownDepartment of Cancer Biology and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-6562-6512
Cancer Research Institute · USUniversity of Pennsylvania · US

Funding

The role of ATR in preventing age-related diseasesR01AG027376 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BROWN, ERIC J · 2006 to 2015
$3.2M
A novel more effective genotoxic therapy for ovarian cancerR37CA215436 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SIMPKINS, FIONA · 2018 to 2024
$2.6M
IDENTIFICATION AND PRECLINICAL EVALUATION OF NOVEL THERAPEUTIC APPROACHES TO DYSKERATOSIS CONGENITAR01HL148821 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JOHNSON, F. BRAD, LENGNER, CHRISTOPHER JOACHIM · 2019 to 2022
$2.5M
Effects of ATR-CHK1 inhibition on genome stability and cancer progressionR01CA189743 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BROWN, ERIC J · 2015 to 2019
$1.8M
Cell-Intrinsic and Extrinsic Factors in Stem Cell AgingF30AG044995 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SMALL, SARA · 2013 to 2016
$104k
NCI NIH HHS R01 CA189743NCI NIH HHS R37 CA215436NHLBI NIH HHS R01 HL148821NIA NIH HHS F30 AG044995NIA NIH HHS R01 AG027376
6 · The paper itself

Abstract

Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and cGAS-STING and that

Indexed as

DNA DamageMembrane ProteinsSignal TransductionAnimalsCytokinesInterleukinsMAP Kinase Signaling SystemMiceNucleotidyltransferasesSTING ProteinCytokinesIl19 protein, mouseInterleukinsMembrane ProteinsNucleotidyltransferasesSting1 protein, mouseSTING Protein

Identifiers

PMID34932373
PMCPMC9218922
OpenAlexW4200313658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.