ArticleJournal of hepato-biliary-pancreatic sciences2022
Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction.
Article in Journal of hepato-biliary-pancreatic sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Sex differences in the association between red cell distribution width and 30-day mortality in critically ill patients with acute cholangitis: a retrospective cohort study.BMC gastroenterology · 2025Article
- Validation of charcot's triad and Tokyo guidelines 2018 as a diagnostic tool for acute ascending cholangitis secondary to a liver cystic echinococcosis.BMC infectious diseases · 2025Article
- Development and validation of a prediction model for cholangitis after percutaneous transhepatic cholangioscopic lithotripsy.Clinical and experimental medicine · 2025Article
- Advances in the Management of Fluid Resuscitation in Acute Pancreatitis: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Efficacy and safety of sequential cutting of nasobiliary tubes as an alternative to stent placement after nasobiliary drainage for the treatment of hilar malignant biliary stricture: a retrospective cohort study.Therapeutic advances in gastroenterology · 2025Article
- Identification of Microbial Species and Analysis of Antimicrobial Resistance Patterns in Acute Cholangitis Patients with Malignant and Benign Biliary Obstructions: A Comparative Study.Medicina (Kaunas, Lithuania) · 2023Article
- Diagnosis, severity stratification and management of adult acute pancreatitis-current evidence and controversies.World journal of gastrointestinal surgery · 2022Review
- Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction.Journal of hepato-biliary-pancreatic sciences · 2022Article
- Endotoxin Activity Assay as a Novel Predictor of Disease Progression in Patients With Mild Cholangitis.In vivo (Athens, Greece)Observational
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundAcute cholangitis is an infection requiring endoscopic retrograde cholangiopancreatography (ERCP) and antibiotics. Several diagnostic tools help to diagnose cholangitis. Because diagnostic performance of these tools has not been studied and might therefore impose unnecessary ERCPs, we aimed to evaluate this.
methodsWe established a nationwide prospective cohort of patients with suspected biliary obstruction who underwent an ERCP. We assessed the diagnostic performance of Tokyo Guidelines (TG18), Dutch Pancreatitis Study Group (DPSG) criteria, and Charcot triad relative to real-world cholangitis as the reference standard.
results127 (16%) of 794 patients were diagnosed with real-world cholangitis. Using the TG18, DPSG, and Charcot triad, 345 (44%), 55 (7%), and 66 (8%) patients were defined as having cholangitis, respectively. Sensitivity for TG18 was 82% (95% CI 74-88) and specificity 60% (95% CI 56-63). The sensitivity for DPSG and Charcot was 42% (95% CI 33-51) and 46% (95% CI 38-56), specificity was 99.7% (95% CI 99-100) and 99% (95% CI 98-100), respectively.
conclusionsTG18 criteria incorrectly diagnoses four out of ten patients with real-world cholangitis, while DPSG and Charcot criteria failed to diagnose more than half of patients. As the cholangitis diagnosis has many consequences for treatment, there is a need for more accurate diagnostic tools or work-up towards ERCP.
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