Evidence map›Paper›PMID 34932179›Full record

ArticleJournal of mammary gland biology and neoplasia2021

Nfatc1's Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal.

Melissa McNeil, Yingying Han, Peng Sun, Kazuhide Watanabe, Jun Jiang, Natasha Chen, Zhengquan Yu, Bin Zhou, Xing Dai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mammary gland biology and neoplasia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Melissa McNeilDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
Yingying HanDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
Peng SunDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
Kazuhide WatanabeDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
Jun JiangDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
Natasha ChenDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
Zhengquan YuState Key Laboratories for Agrobiotechnology, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
Bin ZhouDepartments of Genetics, Pediatrics, and Medicine (Cardiology), The Wilf Cardiovascular Research Institute, The Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Xing DaiDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA. xdai@uci.edu.ORCID 0000-0001-8134-1365
University of California, Irvine · USAlbert Einstein College of Medicine · USChina Agricultural University · CN

Funding

Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
Mammary basal/stem cell plasticity and regulationR01GM123731 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING · 2017 to 2020
$1.9M
Control of epithelial plasticity and differentiation in hair follicle stem/progenitor cellsR01AR068074 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING · 2015 to 2019
$1.7M
NIAMS NIH HHS R01 AR068074NIAMS NIH HHS U01 AR073159NIGMS NIH HHS R01 GM123731
6 · The paper itself

Abstract

Mammary gland is an outstanding system to study the regulatory mechanisms governing adult epithelial stem cell activity. Stem cells in the basal layer of the mammary gland fuel the morphogenesis and regeneration of a complex epithelial network during development and upon transplantation. The self-renewal of basal stem/progenitor cells is subjected to regulation by both cell-intrinsic and extrinsic mechanisms. Nfatc1 is a transcription factor that regulates breast tumorigenesis and metastasis, but its role in mammary epithelial development and stem cell function has not been investigated. Here we show that Nfatc1 is expressed in a small subset of mammary basal epithelial cells and its epithelial-specific deletion results in mild defects in side branching and basal-luminal cell balance. Moreover, Nfatc1-deficient basal cells exhibit reduced colony forming ability in vitro and somewhat compromised regenerative potential upon transplantation. Thus, our study provides evidence for a detectable yet non-essential role of Nfatc1 in mammary epithelial morphogenesis and basal stem/progenitor cell self-renewal.

Indexed as

Mammary Glands, AnimalStem CellsAnimalsCell DifferentiationEpithelial CellsMorphogenesisTranscription FactorsTranscription FactorsBasal cellMammary glandNfatc1Self-renewalStem cell

Identifiers

PMID34932179
PMCPMC8858291
OpenAlexW4200326121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.